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- W2051665745 abstract "Since their inaugural discovery in the early 1960s, matrix metalloproteinases (MMPs) have been shown to mediate multiple physiological and pathological processes. In addition to their canonical function in extracellular matrix (ECM) remodeling, research in the last decade has highlighted new MMP functions, including proteolysis of novel substrates beyond ECM proteins, MMP localization to subcellular organelles, and proteolysis of susceptible intracellular proteins in those subcellular compartments. This review will provide a comparison of the extracellular and intracellular roles of MMPs, illustrating that MMPs are far more interesting than the one-dimensional view originally taken. We focus on the roles of MMP-2 in cardiac injury and repair, as this is one of the most studied MMPs in the cardiovascular field. We will highlight how understanding all dimensions, such as localization of activity and timing of interventions, will increase the translational potential of research findings. Building upon old ideas and turning them inside out and upside down will help us to better understand how to move the MMP field forward." @default.
- W2051665745 created "2016-06-24" @default.
- W2051665745 creator A5003150097 @default.
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- W2051665745 creator A5054514855 @default.
- W2051665745 creator A5055221470 @default.
- W2051665745 creator A5058202537 @default.
- W2051665745 date "2014-12-01" @default.
- W2051665745 modified "2023-10-08" @default.
- W2051665745 title "Myocardial matrix metalloproteinase-2: inside out and upside down" @default.
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