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- W2051675295 abstract "7-Methylbenz[a]anthracene (7-MBA) was metabolized stereoselectively by rat liver microsomes to form five optically active dihydrodiols as the predominant metabolites. The dihydrodiols were purified by a combination of reversed-phase and normal-phase high performance liquid chromatography (HPLC). By comparison of their circular dichroism (CD) spectra with the corresponding benz[a]anthracene (BA) dihydrodiols of known absolute stereochemistry, the major dihydrodiol enantiomers of 7-MBA have been determined to have 1R,2R-, 3R,4R- and 10R,11R- absolute configurations, respectively. Due to their quasi-diaxial conformations, the absolute configuration of trans-5,6- and trans-8,9-dihydrodiols, the two most abundant metabolites of 7-MBA, could not be determined by simple comparisons of their circular dichroism spectra with those of the quasidiequatorial BA 5R,6R- and 8R,9R-dihydrodiols. The major enantiomers of the quasi-diaxial trans-5,6- and trans-8,9-dihydrodiol metabolites of 7-MBA were determined by comparison to the CD spectrum of 7-bromo-BA 5R,6R-dihydrodiol and by the exciton chirality method to have R,R absolute stereochemistry. This study also revealed that the circular dichroism Cotton effects of an enantiomeric dihydrodiol of polycyclic aromatic hydrocarbons can be drastically altered if the conformation (quasi-diaxial vs. quasi-diequatorial) of the dihydrodiol is changed." @default.
- W2051675295 created "2016-06-24" @default.
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- W2051675295 date "1984-04-01" @default.
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- W2051675295 title "Stereoselective metabolism of 7-methylbenz[a]anthracene: Absolute configuration of five dihydrodiol metabolites and the effect of dihydrodiol conformation on circular dichroism spectra" @default.
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- W2051675295 doi "https://doi.org/10.1016/0009-2797(84)90053-x" @default.
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