Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051696362> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2051696362 abstract "Introduction: Dysplasia and early cancer of esohagus are often difficult to prove under white-light endoscopy. The present article describes the early detection of these lesions with the help of photodynamic diagnosis (PDD) following photosensibilisation with oral 5-aminolevulinic acid (5-ALA). Methods: Twelve patients with histological proved esophageal squamous cell cancer were sensitized with 5-ALA [10 mg/kg body weight (n=7), 15 mg/kg body weight (n=5)] orally. Three hours (n=2) or six hours (n=10) later patients underwent endoscopic fluorescence detection using a special light source capable of delivering either white light for conventional endoscopy or violet-blue light for endoscopic fluorescence detection. Red fluorescence was recorded via the gastroscope using an image-intensifying camera. Results: In total 48 biopsies were taken, 21 from non-fluorescing mucosa and 27 from red-fluorescing mucosa. Nine of ten biopsies taken from histological proved malignant areas showed red fluorescence. 20 of 38 histological benign biopsies were classified as fluorescence-negative using PDD. Using histology as gold-standard, sensitivity for PDD was 90.0 % versus 20.0 % for white-light endoscopy, while specificity for PDD was only 52.6 % versus 92.1 % for endoscopic white light image. Discussion: With a sensitivity of 90 % PDD is an appropriate method to detect (pre-)cancerous lesions potentially at an earlier stage in comparison with white-light endoscopy (sens. 20 %). Though PDD has a lower specificity (52.6 % versus 92.1 % with white-light), especially high risk patients might profit from this procedure." @default.
- W2051696362 created "2016-06-24" @default.
- W2051696362 creator A5004312543 @default.
- W2051696362 creator A5060305630 @default.
- W2051696362 creator A5078757787 @default.
- W2051696362 creator A5086959830 @default.
- W2051696362 date "2000-04-01" @default.
- W2051696362 modified "2023-09-26" @default.
- W2051696362 title "3452 Endoscopic photodynamic diagnosis for the detection of dysplasia and squamous cell cancer of the esophagus." @default.
- W2051696362 doi "https://doi.org/10.1016/s0016-5107(00)14152-5" @default.
- W2051696362 hasPublicationYear "2000" @default.
- W2051696362 type Work @default.
- W2051696362 sameAs 2051696362 @default.
- W2051696362 citedByCount "0" @default.
- W2051696362 crossrefType "journal-article" @default.
- W2051696362 hasAuthorship W2051696362A5004312543 @default.
- W2051696362 hasAuthorship W2051696362A5060305630 @default.
- W2051696362 hasAuthorship W2051696362A5078757787 @default.
- W2051696362 hasAuthorship W2051696362A5086959830 @default.
- W2051696362 hasConcept C121608353 @default.
- W2051696362 hasConcept C126322002 @default.
- W2051696362 hasConcept C126838900 @default.
- W2051696362 hasConcept C142724271 @default.
- W2051696362 hasConcept C2775894508 @default.
- W2051696362 hasConcept C2777819096 @default.
- W2051696362 hasConcept C2778451229 @default.
- W2051696362 hasConcept C57742111 @default.
- W2051696362 hasConcept C71924100 @default.
- W2051696362 hasConcept C90924648 @default.
- W2051696362 hasConceptScore W2051696362C121608353 @default.
- W2051696362 hasConceptScore W2051696362C126322002 @default.
- W2051696362 hasConceptScore W2051696362C126838900 @default.
- W2051696362 hasConceptScore W2051696362C142724271 @default.
- W2051696362 hasConceptScore W2051696362C2775894508 @default.
- W2051696362 hasConceptScore W2051696362C2777819096 @default.
- W2051696362 hasConceptScore W2051696362C2778451229 @default.
- W2051696362 hasConceptScore W2051696362C57742111 @default.
- W2051696362 hasConceptScore W2051696362C71924100 @default.
- W2051696362 hasConceptScore W2051696362C90924648 @default.
- W2051696362 hasLocation W20516963621 @default.
- W2051696362 hasOpenAccess W2051696362 @default.
- W2051696362 hasPrimaryLocation W20516963621 @default.
- W2051696362 hasRelatedWork W1966499603 @default.
- W2051696362 hasRelatedWork W1982781387 @default.
- W2051696362 hasRelatedWork W1984820617 @default.
- W2051696362 hasRelatedWork W2007346967 @default.
- W2051696362 hasRelatedWork W2030648845 @default.
- W2051696362 hasRelatedWork W2051363807 @default.
- W2051696362 hasRelatedWork W2058188604 @default.
- W2051696362 hasRelatedWork W2063253690 @default.
- W2051696362 hasRelatedWork W2088861762 @default.
- W2051696362 hasRelatedWork W2090520054 @default.
- W2051696362 hasRelatedWork W2108083871 @default.
- W2051696362 hasRelatedWork W2126293994 @default.
- W2051696362 hasRelatedWork W2335312307 @default.
- W2051696362 hasRelatedWork W2362966721 @default.
- W2051696362 hasRelatedWork W2380675804 @default.
- W2051696362 hasRelatedWork W2402638134 @default.
- W2051696362 hasRelatedWork W2590579575 @default.
- W2051696362 hasRelatedWork W3017197858 @default.
- W2051696362 hasRelatedWork W2577039293 @default.
- W2051696362 hasRelatedWork W2618515982 @default.
- W2051696362 isParatext "false" @default.
- W2051696362 isRetracted "false" @default.
- W2051696362 magId "2051696362" @default.
- W2051696362 workType "article" @default.