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• W2051714733 abstract "The structure of a complex between a bivalent diabody and its antigen, influenza neuraminidase, has been determined by electron cryomicroscopy of single particles and image analysis. A three-dimensional reconstruction has been interpreted in terms of high-resolution X-ray models of the component proteins. The complex consists of two neuraminidase tetramers cross-linked by four diabodies with 422 point symmetry. The structure and symmetry of the complex is determined uniquely by packing constraints consistent with the maximum possible number of diabody cross-links. Diabodies may provide a useful approach to the structure determination of small proteins by incorporating the proteins into large symmetric complexes followed by single-particle electron microscopy." @default.
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• W2051714733 date "2003-12-01" @default.
• W2051714733 modified "2023-10-09" @default.
• W2051714733 title "Structure of an Influenza Neuraminidase–Diabody Complex by Electron Cryomicroscopy and Image Analysis" @default.
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• W2051714733 doi "https://doi.org/10.1016/j.jmb.2003.09.077" @default.
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