Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051720822> ?p ?o ?g. }
- W2051720822 abstract "Abstract We have previously shown that the passive administration of IgM anti-K1 capsular monoclonal antibody (MAb) or IgG3 anti-018 LPS MAb is each highly protective against lethal infection with Escherichia coli 018:K1. We therefore examined whether a combination of these two MAbs against different surface moieties on the same organism might offer greater protection than either MAb alone. Suboptimal concentrations of MAb were given intraperitoneally (i.p.) to ICR mice 2 h before i.p. challenge with 3–6 LD 50 s of E. coli 018:K1. The survival at 7 days for animals pretreated with the combination of MAbs (59%) was not significantly different from mice treated with either the anti-K1 MAb (69%) or anti-lipopolysaccharide (LPS) MAb (46%) alone. The combination of MAbs used at optimal concentrations did provide enhanced protection against a bacterial challenge of 50 LD 50 s under narrowly defined conditions. When a heterologous MAb or a non-protective concentration of anti-LPS MAb was given with the anti-K1 MAb there was an increased mortality associated with the MAb combination. These data suggest that for prevention of bacteremia caused by E. coli 018:K1, (1) there exists a complex relationship between dose of MAb and bacterial inoculum, (2) an anti-LPS antibody may be as protective as an anti-capsular antibody, and (3) interaction among antibody combinations may occur that can impair optimal efficacy." @default.
- W2051720822 created "2016-06-24" @default.
- W2051720822 creator A5003385022 @default.
- W2051720822 creator A5034781292 @default.
- W2051720822 creator A5072556191 @default.
- W2051720822 creator A5089563252 @default.
- W2051720822 date "1988-04-01" @default.
- W2051720822 modified "2023-09-26" @default.
- W2051720822 title "Use of monoclonal antibody combinations in the prevention of bacteremia caused by Escherichia coli 018:K1:H7" @default.
- W2051720822 cites W1496261558 @default.
- W2051720822 cites W1497220185 @default.
- W2051720822 cites W1543028214 @default.
- W2051720822 cites W1545901616 @default.
- W2051720822 cites W1762413315 @default.
- W2051720822 cites W1807470715 @default.
- W2051720822 cites W1829446598 @default.
- W2051720822 cites W1899670912 @default.
- W2051720822 cites W1904058845 @default.
- W2051720822 cites W1909024074 @default.
- W2051720822 cites W1929979497 @default.
- W2051720822 cites W1961875834 @default.
- W2051720822 cites W1986147894 @default.
- W2051720822 cites W1987426585 @default.
- W2051720822 cites W1991844560 @default.
- W2051720822 cites W2012113843 @default.
- W2051720822 cites W2027598363 @default.
- W2051720822 cites W2029600545 @default.
- W2051720822 cites W2031181168 @default.
- W2051720822 cites W2042894336 @default.
- W2051720822 cites W2043274484 @default.
- W2051720822 cites W2063042741 @default.
- W2051720822 cites W2064153395 @default.
- W2051720822 cites W2074899272 @default.
- W2051720822 cites W2130036682 @default.
- W2051720822 cites W2131685987 @default.
- W2051720822 cites W2146835611 @default.
- W2051720822 cites W2151591864 @default.
- W2051720822 cites W2157314723 @default.
- W2051720822 cites W2256756668 @default.
- W2051720822 cites W3217730596 @default.
- W2051720822 doi "https://doi.org/10.1016/0888-0786(88)90046-7" @default.
- W2051720822 hasPublicationYear "1988" @default.
- W2051720822 type Work @default.
- W2051720822 sameAs 2051720822 @default.
- W2051720822 citedByCount "0" @default.
- W2051720822 crossrefType "journal-article" @default.
- W2051720822 hasAuthorship W2051720822A5003385022 @default.
- W2051720822 hasAuthorship W2051720822A5034781292 @default.
- W2051720822 hasAuthorship W2051720822A5072556191 @default.
- W2051720822 hasAuthorship W2051720822A5089563252 @default.
- W2051720822 hasConcept C104317684 @default.
- W2051720822 hasConcept C159654299 @default.
- W2051720822 hasConcept C163864487 @default.
- W2051720822 hasConcept C185592680 @default.
- W2051720822 hasConcept C203014093 @default.
- W2051720822 hasConcept C2778754761 @default.
- W2051720822 hasConcept C2778910516 @default.
- W2051720822 hasConcept C2779443120 @default.
- W2051720822 hasConcept C2780115692 @default.
- W2051720822 hasConcept C501593827 @default.
- W2051720822 hasConcept C523546767 @default.
- W2051720822 hasConcept C542903549 @default.
- W2051720822 hasConcept C54355233 @default.
- W2051720822 hasConcept C547475151 @default.
- W2051720822 hasConcept C55493867 @default.
- W2051720822 hasConcept C86803240 @default.
- W2051720822 hasConcept C89423630 @default.
- W2051720822 hasConceptScore W2051720822C104317684 @default.
- W2051720822 hasConceptScore W2051720822C159654299 @default.
- W2051720822 hasConceptScore W2051720822C163864487 @default.
- W2051720822 hasConceptScore W2051720822C185592680 @default.
- W2051720822 hasConceptScore W2051720822C203014093 @default.
- W2051720822 hasConceptScore W2051720822C2778754761 @default.
- W2051720822 hasConceptScore W2051720822C2778910516 @default.
- W2051720822 hasConceptScore W2051720822C2779443120 @default.
- W2051720822 hasConceptScore W2051720822C2780115692 @default.
- W2051720822 hasConceptScore W2051720822C501593827 @default.
- W2051720822 hasConceptScore W2051720822C523546767 @default.
- W2051720822 hasConceptScore W2051720822C542903549 @default.
- W2051720822 hasConceptScore W2051720822C54355233 @default.
- W2051720822 hasConceptScore W2051720822C547475151 @default.
- W2051720822 hasConceptScore W2051720822C55493867 @default.
- W2051720822 hasConceptScore W2051720822C86803240 @default.
- W2051720822 hasConceptScore W2051720822C89423630 @default.
- W2051720822 hasLocation W20517208221 @default.
- W2051720822 hasOpenAccess W2051720822 @default.
- W2051720822 hasPrimaryLocation W20517208221 @default.
- W2051720822 hasRelatedWork W1829446598 @default.
- W2051720822 hasRelatedWork W1945584064 @default.
- W2051720822 hasRelatedWork W1948497756 @default.
- W2051720822 hasRelatedWork W1973841625 @default.
- W2051720822 hasRelatedWork W1978352742 @default.
- W2051720822 hasRelatedWork W1981062407 @default.
- W2051720822 hasRelatedWork W2005763312 @default.
- W2051720822 hasRelatedWork W2043710199 @default.
- W2051720822 hasRelatedWork W2044479428 @default.
- W2051720822 hasRelatedWork W2056580329 @default.
- W2051720822 hasRelatedWork W2106773202 @default.
- W2051720822 hasRelatedWork W2128797864 @default.
- W2051720822 hasRelatedWork W2139014281 @default.