FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051730836> ?p ?o ?g. }

• W2051730836 abstract "Endurance athletes exhibit sinus bradycardia, that is a slow resting heart rate, associated with a higher incidence of sinus node (pacemaker) disease and electronic pacemaker implantation. Here we show that training-induced bradycardia is not a consequence of changes in the activity of the autonomic nervous system but is caused by intrinsic electrophysiological changes in the sinus node. We demonstrate that training-induced bradycardia persists after blockade of the autonomous nervous system in vivo in mice and in vitro in the denervated sinus node. We also show that a widespread remodelling of pacemaker ion channels, notably a downregulation of HCN4 and the corresponding ionic current, If. Block of If abolishes the difference in heart rate between trained and sedentary animals in vivo and in vitro. We further observe training-induced downregulation of Tbx3 and upregulation of NRSF and miR-1 (transcriptional regulators) that explains the downregulation of HCN4. Our findings provide a molecular explanation for the potentially pathological heart rate adaptation to exercise training." @default.
• W2051730836 created "2016-06-24" @default.
• W2051730836 creator A5002779808 @default.
• W2051730836 creator A5012242509 @default.
• W2051730836 creator A5013301471 @default.
• W2051730836 creator A5020318266 @default.
• W2051730836 creator A5028964368 @default.
• W2051730836 creator A5033914075 @default.
• W2051730836 creator A5037960976 @default.
• W2051730836 creator A5038917567 @default.
• W2051730836 creator A5052719068 @default.
• W2051730836 creator A5055939400 @default.
• W2051730836 creator A5068461349 @default.
• W2051730836 creator A5068645723 @default.
• W2051730836 creator A5074321473 @default.
• W2051730836 creator A5088464141 @default.
• W2051730836 date "2014-05-13" @default.
• W2051730836 modified "2023-10-11" @default.
• W2051730836 title "Exercise training reduces resting heart rate via downregulation of the funny channel HCN4" @default.
• W2051730836 cites W1884338871 @default.
• W2051730836 cites W1903925553 @default.
• W2051730836 cites W1925411411 @default.
• W2051730836 cites W1931248805 @default.
• W2051730836 cites W1968560076 @default.
• W2051730836 cites W1971234199 @default.
• W2051730836 cites W1980516225 @default.
• W2051730836 cites W1994029818 @default.
• W2051730836 cites W199998949 @default.
• W2051730836 cites W2013696266 @default.
• W2051730836 cites W2014268281 @default.
• W2051730836 cites W2031804346 @default.
• W2051730836 cites W2034998169 @default.
• W2051730836 cites W2037765284 @default.
• W2051730836 cites W2039208113 @default.
• W2051730836 cites W2040437516 @default.
• W2051730836 cites W2041485635 @default.
• W2051730836 cites W2048296508 @default.
• W2051730836 cites W2054358450 @default.
• W2051730836 cites W2064461784 @default.
• W2051730836 cites W2064528811 @default.
• W2051730836 cites W2067931814 @default.
• W2051730836 cites W2074142746 @default.
• W2051730836 cites W2077028383 @default.
• W2051730836 cites W2084874490 @default.
• W2051730836 cites W2085982621 @default.
• W2051730836 cites W2088386461 @default.
• W2051730836 cites W2088510916 @default.
• W2051730836 cites W2096363558 @default.
• W2051730836 cites W2097328834 @default.
• W2051730836 cites W2098329812 @default.
• W2051730836 cites W2099632294 @default.
• W2051730836 cites W2102452201 @default.
• W2051730836 cites W2107276575 @default.
• W2051730836 cites W2109126721 @default.
• W2051730836 cites W2109153798 @default.
• W2051730836 cites W2112607700 @default.
• W2051730836 cites W2113881585 @default.
• W2051730836 cites W2123803649 @default.
• W2051730836 cites W2126025637 @default.
• W2051730836 cites W2135148610 @default.
• W2051730836 cites W2135491838 @default.
• W2051730836 cites W2136418621 @default.
• W2051730836 cites W2139552357 @default.
• W2051730836 cites W2146629694 @default.
• W2051730836 cites W2148889365 @default.
• W2051730836 cites W2151619664 @default.
• W2051730836 cites W2156727166 @default.
• W2051730836 cites W2159441016 @default.
• W2051730836 cites W2160706532 @default.
• W2051730836 cites W2161163873 @default.
• W2051730836 cites W2164300147 @default.
• W2051730836 cites W2164308224 @default.
• W2051730836 cites W2167323620 @default.
• W2051730836 cites W2168473939 @default.
• W2051730836 cites W2168881898 @default.
• W2051730836 cites W2547245072 @default.
• W2051730836 cites W4291237095 @default.
• W2051730836 doi "https://doi.org/10.1038/ncomms4775" @default.
• W2051730836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4024745" @default.
• W2051730836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24825544" @default.
• W2051730836 hasPublicationYear "2014" @default.
• W2051730836 type Work @default.
• W2051730836 sameAs 2051730836 @default.
• W2051730836 citedByCount "183" @default.
• W2051730836 countsByYear W20517308362014 @default.
• W2051730836 countsByYear W20517308362015 @default.
• W2051730836 countsByYear W20517308362016 @default.
• W2051730836 countsByYear W20517308362017 @default.
• W2051730836 countsByYear W20517308362018 @default.
• W2051730836 countsByYear W20517308362019 @default.
• W2051730836 countsByYear W20517308362020 @default.
• W2051730836 countsByYear W20517308362021 @default.
• W2051730836 countsByYear W20517308362022 @default.
• W2051730836 countsByYear W20517308362023 @default.
• W2051730836 crossrefType "journal-article" @default.
• W2051730836 hasAuthorship W2051730836A5002779808 @default.
• W2051730836 hasAuthorship W2051730836A5012242509 @default.
• W2051730836 hasAuthorship W2051730836A5013301471 @default.
• W2051730836 hasAuthorship W2051730836A5020318266 @default.
• W2051730836 hasAuthorship W2051730836A5028964368 @default.

• next