Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051732871> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2051732871 endingPage "e329" @default.
- W2051732871 startingPage "e329" @default.
- W2051732871 abstract "Background: Survival following acute infection with Salmonella Typhimurium, a systemic infection modelling human typhoid fever, is dependent upon a coordinated and genetically complex immune response. Methods: We have screened a panel of recombinant congenic strains (RCS) derived from reciprocal double backcrosses between A/J and C57BL/6J for their susceptibility to Salmonella infection. C57BL/6J mice carry a non-functional allele at Slc11a1 (also known as Nramp1), a major determinant of the host response to Salmonella infection. Results: Among the RCS carrying a wild-type allele at Slc11a1, we have identified four deviant strains. The strains AcB61 and AcB62 were extremely susceptible to infection and the strains AcB60 and AcB64 were more resistant than their resistant parent, A/J. Fully informative crosses using AcB61 and AcB64 mice allowed the identification of 5 loci, Ity4 (Immunity to Typhimurium locus 4) and Ity5 in AcB61 and Ity6, Ity7 and Ity8 in AcB64. Ity5 was validated in a genetic environment free of the impact of Ity4 using a cross between A/J and 129S6. Ity8 on Chr15 was validated using an (AcB60 x DBA/2J) F2 population. Using genome-wide transcription profiling and fine mapping, informed through the exploitation of bioinformatics resources, we have identified candidate genes underlying the Ity5 and Ity8 loci. Using both DNA and RNA sequencing, as well as analysis of gene expression (Q-PCR) we have characterized the impact of positional candidate genes for both Ity5 and Ity8on the host-response to Salmonella infection. Conclusion: Through the characterization of the Ity5and Ity8 susceptibility and resistance loci these results provide new insight into the pathogenesis of Salmonella infection and further illuminate the genetic elements of the host immune response to the mouse model of Typhoid fever." @default.
- W2051732871 created "2016-06-24" @default.
- W2051732871 creator A5002954554 @default.
- W2051732871 creator A5025049839 @default.
- W2051732871 creator A5078802242 @default.
- W2051732871 date "2012-06-01" @default.
- W2051732871 modified "2023-09-27" @default.
- W2051732871 title "The AcB61 and AcB60 recombinant congenic strains of inbred mice: susceptibility and resistance to a mouse model of human typhoid fever" @default.
- W2051732871 doi "https://doi.org/10.1016/j.ijid.2012.05.381" @default.
- W2051732871 hasPublicationYear "2012" @default.
- W2051732871 type Work @default.
- W2051732871 sameAs 2051732871 @default.
- W2051732871 citedByCount "0" @default.
- W2051732871 crossrefType "journal-article" @default.
- W2051732871 hasAuthorship W2051732871A5002954554 @default.
- W2051732871 hasAuthorship W2051732871A5025049839 @default.
- W2051732871 hasAuthorship W2051732871A5078802242 @default.
- W2051732871 hasBestOaLocation W20517328711 @default.
- W2051732871 hasConcept C104317684 @default.
- W2051732871 hasConcept C144024400 @default.
- W2051732871 hasConcept C149923435 @default.
- W2051732871 hasConcept C159047783 @default.
- W2051732871 hasConcept C180754005 @default.
- W2051732871 hasConcept C2778782520 @default.
- W2051732871 hasConcept C2781065037 @default.
- W2051732871 hasConcept C2908647359 @default.
- W2051732871 hasConcept C40767141 @default.
- W2051732871 hasConcept C520601542 @default.
- W2051732871 hasConcept C523546767 @default.
- W2051732871 hasConcept C54355233 @default.
- W2051732871 hasConcept C76725341 @default.
- W2051732871 hasConcept C81941488 @default.
- W2051732871 hasConcept C84597430 @default.
- W2051732871 hasConcept C84951073 @default.
- W2051732871 hasConcept C86803240 @default.
- W2051732871 hasConcept C8891405 @default.
- W2051732871 hasConceptScore W2051732871C104317684 @default.
- W2051732871 hasConceptScore W2051732871C144024400 @default.
- W2051732871 hasConceptScore W2051732871C149923435 @default.
- W2051732871 hasConceptScore W2051732871C159047783 @default.
- W2051732871 hasConceptScore W2051732871C180754005 @default.
- W2051732871 hasConceptScore W2051732871C2778782520 @default.
- W2051732871 hasConceptScore W2051732871C2781065037 @default.
- W2051732871 hasConceptScore W2051732871C2908647359 @default.
- W2051732871 hasConceptScore W2051732871C40767141 @default.
- W2051732871 hasConceptScore W2051732871C520601542 @default.
- W2051732871 hasConceptScore W2051732871C523546767 @default.
- W2051732871 hasConceptScore W2051732871C54355233 @default.
- W2051732871 hasConceptScore W2051732871C76725341 @default.
- W2051732871 hasConceptScore W2051732871C81941488 @default.
- W2051732871 hasConceptScore W2051732871C84597430 @default.
- W2051732871 hasConceptScore W2051732871C84951073 @default.
- W2051732871 hasConceptScore W2051732871C86803240 @default.
- W2051732871 hasConceptScore W2051732871C8891405 @default.
- W2051732871 hasLocation W20517328711 @default.
- W2051732871 hasOpenAccess W2051732871 @default.
- W2051732871 hasPrimaryLocation W20517328711 @default.
- W2051732871 hasRelatedWork W1971916225 @default.
- W2051732871 hasRelatedWork W2018900847 @default.
- W2051732871 hasRelatedWork W2051732871 @default.
- W2051732871 hasRelatedWork W2065360359 @default.
- W2051732871 hasRelatedWork W2097042684 @default.
- W2051732871 hasRelatedWork W2110282787 @default.
- W2051732871 hasRelatedWork W2117171333 @default.
- W2051732871 hasRelatedWork W2120777818 @default.
- W2051732871 hasRelatedWork W2121444932 @default.
- W2051732871 hasRelatedWork W2488244833 @default.
- W2051732871 hasVolume "16" @default.
- W2051732871 isParatext "false" @default.
- W2051732871 isRetracted "false" @default.
- W2051732871 magId "2051732871" @default.
- W2051732871 workType "article" @default.