FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051733618> ?p ?o ?g. }

• W2051733618 endingPage "4138" @default.
• W2051733618 startingPage "4126" @default.
• W2051733618 abstract "During mitosis, the Xenopus chromokinesin Kid (Xkid) provides the polar ejection forces needed at metaphase for chromosome congression, and its degradation is required at anaphase to induce chromosome segregation. Despite the fact that the degradation of Xkid at anaphase seems to be a key regulatory factor to induce chromosome movement to the poles, little is known about the mechanisms controlling this proteolysis. We investigated here the degradation pathway of Xkid. We demonstrate that Xkid is degraded both in vitro and in vivo by APC/Cdc20 and APC/Cdh1. We show that, despite the presence of five putative D-box motifs in its sequence, Xkid is proteolyzed in a D-box-independent manner. We identify a domain within the C terminus of this chromokinesin, with sequence GxEN, whose mutation completely stabilizes this protein by both APC/Cdc20 and APC/Cdh1. Moreover, we show that this degradation sequence acts as a transposable motif and induces the proteolysis of a GST-GXEN fusion protein. Finally, we demonstrate that both a D-box and a GXEN-containing peptides completely block APC-dependent degradation of cyclin B and Xkid, indicating that the GXEN domain might mediate the recognition and association of Xkid with the APC." @default.
• W2051733618 created "2016-06-24" @default.
• W2051733618 creator A5011636118 @default.
• W2051733618 creator A5040633585 @default.
• W2051733618 creator A5081755542 @default.
• W2051733618 creator A5089304873 @default.
• W2051733618 date "2003-06-01" @default.
• W2051733618 modified "2023-09-27" @default.
• W2051733618 title "Xkid Is Degraded in a D-Box, KEN-Box, and A-Box-Independent Pathway" @default.
• W2051733618 cites W1531694332 @default.
• W2051733618 cites W1804270252 @default.
• W2051733618 cites W1972974768 @default.
• W2051733618 cites W1977576010 @default.
• W2051733618 cites W1987914156 @default.
• W2051733618 cites W1990368851 @default.
• W2051733618 cites W1991101546 @default.
• W2051733618 cites W1993141678 @default.
• W2051733618 cites W2000921861 @default.
• W2051733618 cites W2007853809 @default.
• W2051733618 cites W2014418233 @default.
• W2051733618 cites W2015851881 @default.
• W2051733618 cites W2020438166 @default.
• W2051733618 cites W2024066421 @default.
• W2051733618 cites W2026033647 @default.
• W2051733618 cites W2033141310 @default.
• W2051733618 cites W2036530157 @default.
• W2051733618 cites W2036856219 @default.
• W2051733618 cites W2038197766 @default.
• W2051733618 cites W2038369521 @default.
• W2051733618 cites W2044570417 @default.
• W2051733618 cites W2060328544 @default.
• W2051733618 cites W2063759666 @default.
• W2051733618 cites W2070873192 @default.
• W2051733618 cites W2090109154 @default.
• W2051733618 cites W2094247207 @default.
• W2051733618 cites W2096904713 @default.
• W2051733618 cites W2102230270 @default.
• W2051733618 cites W2106869142 @default.
• W2051733618 cites W2109845164 @default.
• W2051733618 cites W2112854488 @default.
• W2051733618 cites W2114070867 @default.
• W2051733618 cites W2125240364 @default.
• W2051733618 cites W2126955433 @default.
• W2051733618 cites W2127895252 @default.
• W2051733618 cites W2129723437 @default.
• W2051733618 cites W2131403694 @default.
• W2051733618 cites W2136644864 @default.
• W2051733618 cites W2141627232 @default.
• W2051733618 cites W2142790777 @default.
• W2051733618 cites W2146084258 @default.
• W2051733618 cites W2148418137 @default.
• W2051733618 cites W2150922649 @default.
• W2051733618 cites W2151759271 @default.
• W2051733618 cites W2159258787 @default.
• W2051733618 cites W2160567919 @default.
• W2051733618 cites W2324763502 @default.
• W2051733618 cites W86875131 @default.
• W2051733618 doi "https://doi.org/10.1128/mcb.23.12.4126-4138.2003" @default.
• W2051733618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/156142" @default.
• W2051733618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12773557" @default.
• W2051733618 hasPublicationYear "2003" @default.
• W2051733618 type Work @default.
• W2051733618 sameAs 2051733618 @default.
• W2051733618 citedByCount "68" @default.
• W2051733618 countsByYear W20517336182012 @default.
• W2051733618 countsByYear W20517336182013 @default.
• W2051733618 countsByYear W20517336182014 @default.
• W2051733618 countsByYear W20517336182015 @default.
• W2051733618 countsByYear W20517336182016 @default.
• W2051733618 countsByYear W20517336182017 @default.
• W2051733618 countsByYear W20517336182018 @default.
• W2051733618 countsByYear W20517336182019 @default.
• W2051733618 countsByYear W20517336182020 @default.
• W2051733618 countsByYear W20517336182021 @default.
• W2051733618 countsByYear W20517336182022 @default.
• W2051733618 crossrefType "journal-article" @default.
• W2051733618 hasAuthorship W2051733618A5011636118 @default.
• W2051733618 hasAuthorship W2051733618A5040633585 @default.
• W2051733618 hasAuthorship W2051733618A5081755542 @default.
• W2051733618 hasAuthorship W2051733618A5089304873 @default.
• W2051733618 hasBestOaLocation W20517336181 @default.
• W2051733618 hasConcept C104317684 @default.
• W2051733618 hasConcept C153911025 @default.
• W2051733618 hasConcept C181199279 @default.
• W2051733618 hasConcept C2778354886 @default.
• W2051733618 hasConcept C2779535977 @default.
• W2051733618 hasConcept C2781125876 @default.
• W2051733618 hasConcept C2781307694 @default.
• W2051733618 hasConcept C29537977 @default.
• W2051733618 hasConcept C30481170 @default.
• W2051733618 hasConcept C53420372 @default.
• W2051733618 hasConcept C54355233 @default.
• W2051733618 hasConcept C55493867 @default.
• W2051733618 hasConcept C70278784 @default.
• W2051733618 hasConcept C86803240 @default.
• W2051733618 hasConcept C93304396 @default.
• W2051733618 hasConcept C95444343 @default.
• W2051733618 hasConceptScore W2051733618C104317684 @default.

• next