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• W2051741567 abstract "Noguchi et al1Noguchi E Shibasaki M Inudou M et al.Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels.J Allergy Clin Immunol. 2001; 108: 382-386Abstract Full Text Full Text PDF PubMed Scopus (36) Google Scholar have recently identified 3 novel polymorphisms (5923 A/G, 7888 C/T, 8578 A/C) and a rare variant (Arg25Cys) in the gene encoding activation-induced cytidine deaminase (AID). The AID gene is a putative RNA-editing deaminase2Muto T Muramatsu M Taniwaki M Kinoshita K Honjo T. Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.Genomics. 2000; 68: 85-88Crossref PubMed Scopus (126) Google Scholar member of the cytosine deaminase family that encodes a 198-amino-acid protein involved in class switch recombination and somatic hypermutation.3Revy P Muto T Levy Y et al.Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).Cell. 2000; 102: 565-575Abstract Full Text Full Text PDF PubMed Scopus (1356) Google Scholar In their study Noguchi et al1Noguchi E Shibasaki M Inudou M et al.Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels.J Allergy Clin Immunol. 2001; 108: 382-386Abstract Full Text Full Text PDF PubMed Scopus (36) Google Scholar conclude that polymorphism 7888 C/T (a silent mutation located in exon 4) in the AID gene might be associated with the pathogenesis of atopic asthma and with the regulation of total serum IgE levels. We have analyzed the 7888 C/T polymorphism of AID in a Spanish population. One hundred twelve adult subjects recruited from the Allergy Department of the University Hospital of Salamanca (Spain) were studied. Sixty-seven patients were atopic, and 44 of them presented with atopic asthma. Forty-five subjects were considered control subjects. After PCR amplification, the 7888 C/T polymorphism was identified by the gain of an Nla III restriction site.1Noguchi E Shibasaki M Inudou M et al.Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels.J Allergy Clin Immunol. 2001; 108: 382-386Abstract Full Text Full Text PDF PubMed Scopus (36) Google Scholar As shown in Table I, we have not found any association between the 7888 C/T polymorphism and the presence of atopic asthma. Table IDistribution of patients with the 7888C allele according to the presence of atopy, atopic asthma, and total serum IgE levelsAtopy, n = 112 (%)Atopic asthma, n = 112 (%)Total IgE levels, n = 112 (%)Yes, n = 67No, n = 45Yes, n = 44No, n = 68>100 kU/L, n = 56<100 kU/L, n = 567888 C positive44 (65.7)33 (73.3)29 (66)48 (70.6)39 (69.6)38 (68)7888 C negative23 (34.3)12 (26.7)15 (34)20 (29.4)17 (30.4)18 (32) Open table in a new tab We have also analyzed the possible relationship between this polymorphism and IgE levels. Patients' IgE levels were similar independently of the allele they carried (Table I). Atopy is a complex disease, and many genes have been implicated in its development. Here we report lack of association between atopic asthma and the 7888 C/T polymorphism of the AID gene. The discrepancy with the results reported by the group of Noguchi et al1Noguchi E Shibasaki M Inudou M et al.Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels.J Allergy Clin Immunol. 2001; 108: 382-386Abstract Full Text Full Text PDF PubMed Scopus (36) Google Scholar could be attributed to the different ethnic background of the subjects included in our series. We think that it is necessary to perform studies in individuals from other races before drawing a definitive conclusion on the influence of the AID gene in atopic asthma and in the regulation of IgE levels." @default.
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• W2051741567 date "2003-08-01" @default.
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• W2051741567 title "Lack of association between the 7888 C/T polymorphism in the AID gene and atopy in a Spanish population" @default.
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• W2051741567 doi "https://doi.org/10.1067/mai.2003.1642" @default.
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