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- W2051751236 abstract "Abstract The metabolic activation of benz(a)anthracene was investigated by incubating [3H]-benz(a)anthracene with DNA, a NADPH-generating system and rat-liver microsomes. When hydrolysates of the DNA were chromatographed on Sephadex LH20 columns, three hydrocarbon-nucleoside adduct peaks were resolved and these were further examined using HPLC. One adduct probably results from the reaction of the non-bay-region diol-epoxide r -8, t -9-dihydroxy- t -10,11-oxy-8,9,10,11-tetrahydrobenz(a)anthracene ( anti -BA-8,9-diol 10,11-oxide) with DNA. The other two adducts did not co-chromatograph with adducts formed from any of the four possible isomeric diolepoxides that can be formed in the 8,9,10,11-ring of benz(a)anthracene." @default.
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- W2051751236 date "1979-11-01" @default.
- W2051751236 modified "2023-10-16" @default.
- W2051751236 title "The involvement of a non-‘bay-region’ diol-epoxide in the formation of benz(a)anthracene-DNA adducts in a rat-liver microsomal system" @default.
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- W2051751236 doi "https://doi.org/10.1016/0006-291x(79)91548-1" @default.
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