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- W2051757093 abstract "Vitamin-K-dependent proteins are found in both the pro- and anti-coagulation cascades, and their use in coagulation therapies is expanding rapidly. The vitamin-K-dependent, gamma-carboxyglutamic acid (Gla)-containing regions of proteins in this family are homologous and are responsible for membrane association. Site-directed mutations that enhance the membrane affinity of protein C, an anticoagulant, and of factor VII, a procoagulant, have been identified. These protein C and Factor VII mutants show enhanced activity in many assays, offering opportunities to study the role of membrane in blood clotting reactions and proteins that may have greater therapeutic value." @default.
- W2051757093 created "2016-06-24" @default.
- W2051757093 creator A5023957817 @default.
- W2051757093 date "1999-08-01" @default.
- W2051757093 modified "2023-10-18" @default.
- W2051757093 title "Enhancement of Vitamin-K-Dependent Protein Function by Modification of the γ-Carboxyglutamic Acid Domain Studies of Protein C and Factor VII" @default.
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- W2051757093 doi "https://doi.org/10.1016/s1050-1738(99)00024-9" @default.
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