Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051764261> ?p ?o ?g. }
- W2051764261 endingPage "104" @default.
- W2051764261 startingPage "93" @default.
- W2051764261 abstract "Nitric oxide (NO) production during hyposmotic stimulation in outer hair cells (OHCs) of the guinea pig cochlea was investigated using the NO sensitive dye DAF-2. Simultaneous measurement of the cell length and NO production showed rapid hyposmotic-induced cell swelling to precede NO production in OHCs. Hyposmotic stimulation failed to induce NO production in the Ca2+-free solution. L-NG-nitroarginine methyl ester (L-NAME), a non-specific NO synthase inhibitor and gadolinium, a stretch-activated channel blocker inhibited the hyposmotic stimulation-induced NO production whereas suramin, a P2 receptor antagonist did not. S-nitroso-N-acetylpenicillamine (SNAP), a NO donor inhibited the hyposmotic stimulation-induced increase in the intracellular Ca2+ concentrations ([Ca2+]i) while L-NAME enhanced it. 1H-[1,2,4]oxadiazole[4,3a]quinoxalin-1-one, an inhibitor of guanylate cyclase and KT5823, an inhibitor of cGMP-dependent protein kinase (PKG) mimicked effects of L-NAME on the Ca2+ response. Transient receptor potential vanilloid 4 (TRPV4), an osmo- and mechanosensitive channel was expressed in the OHCs by means of immunohistochemistry. 4alpha-phorbol 12,13-didecanoate, a TRPV4 synthetic activator, induced NO production in OHCs. These results suggest that hyposmotic stimulation can induce NO production by the [Ca2+]i increase, which is presumably mediated by the activation of TRPV4 in OHCs. NO conversely inhibits the Ca2+ response via the NO-cGMP-PKG pathway by a feedback mechanism." @default.
- W2051764261 created "2016-06-24" @default.
- W2051764261 creator A5016957731 @default.
- W2051764261 creator A5027195265 @default.
- W2051764261 creator A5046625725 @default.
- W2051764261 creator A5053086490 @default.
- W2051764261 creator A5058071677 @default.
- W2051764261 creator A5076608744 @default.
- W2051764261 date "2007-08-01" @default.
- W2051764261 modified "2023-10-05" @default.
- W2051764261 title "Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea" @default.
- W2051764261 cites W1545384325 @default.
- W2051764261 cites W1957884210 @default.
- W2051764261 cites W1969094022 @default.
- W2051764261 cites W1974341170 @default.
- W2051764261 cites W1976307713 @default.
- W2051764261 cites W1978925722 @default.
- W2051764261 cites W1979856671 @default.
- W2051764261 cites W1981858233 @default.
- W2051764261 cites W1984057922 @default.
- W2051764261 cites W1991121028 @default.
- W2051764261 cites W1994158918 @default.
- W2051764261 cites W1994205691 @default.
- W2051764261 cites W1994557292 @default.
- W2051764261 cites W1997848669 @default.
- W2051764261 cites W1999132987 @default.
- W2051764261 cites W1999448332 @default.
- W2051764261 cites W2004274364 @default.
- W2051764261 cites W2009296295 @default.
- W2051764261 cites W2010055809 @default.
- W2051764261 cites W2010712569 @default.
- W2051764261 cites W2011393912 @default.
- W2051764261 cites W2017330689 @default.
- W2051764261 cites W2019595135 @default.
- W2051764261 cites W2024221104 @default.
- W2051764261 cites W2026397278 @default.
- W2051764261 cites W2040501484 @default.
- W2051764261 cites W2043790997 @default.
- W2051764261 cites W2046974797 @default.
- W2051764261 cites W2047105817 @default.
- W2051764261 cites W2047613989 @default.
- W2051764261 cites W2054149684 @default.
- W2051764261 cites W2056560207 @default.
- W2051764261 cites W2061038712 @default.
- W2051764261 cites W2063024150 @default.
- W2051764261 cites W2064467822 @default.
- W2051764261 cites W2069225430 @default.
- W2051764261 cites W2071380676 @default.
- W2051764261 cites W2074276238 @default.
- W2051764261 cites W2076517570 @default.
- W2051764261 cites W2079740701 @default.
- W2051764261 cites W2080015601 @default.
- W2051764261 cites W2080323618 @default.
- W2051764261 cites W2088314252 @default.
- W2051764261 cites W2091898845 @default.
- W2051764261 cites W2093869879 @default.
- W2051764261 cites W2099901207 @default.
- W2051764261 cites W2105036120 @default.
- W2051764261 cites W2118622904 @default.
- W2051764261 cites W2120452447 @default.
- W2051764261 cites W2121381083 @default.
- W2051764261 cites W2125754330 @default.
- W2051764261 cites W2128158693 @default.
- W2051764261 cites W2131711857 @default.
- W2051764261 cites W2136018765 @default.
- W2051764261 cites W2150070295 @default.
- W2051764261 cites W2153224159 @default.
- W2051764261 cites W2162606098 @default.
- W2051764261 cites W2171926789 @default.
- W2051764261 cites W2172527495 @default.
- W2051764261 cites W2173833672 @default.
- W2051764261 cites W335075523 @default.
- W2051764261 cites W4250231884 @default.
- W2051764261 doi "https://doi.org/10.1016/j.heares.2007.05.010" @default.
- W2051764261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17722255" @default.
- W2051764261 hasPublicationYear "2007" @default.
- W2051764261 type Work @default.
- W2051764261 sameAs 2051764261 @default.
- W2051764261 citedByCount "17" @default.
- W2051764261 countsByYear W20517642612012 @default.
- W2051764261 countsByYear W20517642612014 @default.
- W2051764261 countsByYear W20517642612015 @default.
- W2051764261 countsByYear W20517642612016 @default.
- W2051764261 countsByYear W20517642612017 @default.
- W2051764261 countsByYear W20517642612023 @default.
- W2051764261 crossrefType "journal-article" @default.
- W2051764261 hasAuthorship W2051764261A5016957731 @default.
- W2051764261 hasAuthorship W2051764261A5027195265 @default.
- W2051764261 hasAuthorship W2051764261A5046625725 @default.
- W2051764261 hasAuthorship W2051764261A5053086490 @default.
- W2051764261 hasAuthorship W2051764261A5058071677 @default.
- W2051764261 hasAuthorship W2051764261A5076608744 @default.
- W2051764261 hasConcept C105702510 @default.
- W2051764261 hasConcept C126322002 @default.
- W2051764261 hasConcept C134018914 @default.
- W2051764261 hasConcept C155164980 @default.
- W2051764261 hasConcept C170493617 @default.
- W2051764261 hasConcept C185592680 @default.