FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051775752> ?p ?o ?g. }

• W2051775752 endingPage "225" @default.
• W2051775752 startingPage "213" @default.
• W2051775752 abstract "We have identified two N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analogs as a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120–CD4 interaction, using database screening techniques. The lead compounds, NBD-556 and NBD-557, are small molecule organic compounds with drug-like properties. These compounds showed potent cell fusion and virus–cell fusion inhibitory activity at low micromolar levels. A systematic study showed that these compounds target viral entry by inhibiting the binding of HIV-1 envelope glycoprotein gp120 to the cellular receptor CD4 but did not inhibit reverse transcriptase, integrase, or protease, indicating that they do not target the later stages of the HIV-1 life cycle to inhibit HIV-1 infection. These compounds were equally potent inhibitors of both X4 and R5 viruses tested in CXCR4 and CCR5 expressing cell lines, respectively, indicating that their anti-HIV-1 activity is not dependent on the coreceptor tropism of the virus. A surface plasmon resonance study, which measures binding affinity, clearly demonstrated that these compounds bind to unliganded HIV-1 gp120 but not to the cellular receptor CD4. NBD-556 and NBD-557 were active against HIV-1 laboratory-adapted strains including an AZT-resistant strain and HIV-1 primary isolates, indicating that these compounds can potentially be further modified to become potent HIV-1 entry inhibitors." @default.
• W2051775752 created "2016-06-24" @default.
• W2051775752 creator A5004696190 @default.
• W2051775752 creator A5006925420 @default.
• W2051775752 creator A5023220693 @default.
• W2051775752 creator A5025375416 @default.
• W2051775752 creator A5047077004 @default.
• W2051775752 creator A5054808938 @default.
• W2051775752 creator A5057428201 @default.
• W2051775752 creator A5069302796 @default.
• W2051775752 creator A5088170766 @default.
• W2051775752 date "2005-09-01" @default.
• W2051775752 modified "2023-10-16" @default.
• W2051775752 title "Identification of N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4" @default.
• W2051775752 cites W123287245 @default.
• W2051775752 cites W1490369813 @default.
• W2051775752 cites W1607434342 @default.
• W2051775752 cites W1628484047 @default.
• W2051775752 cites W1775940529 @default.
• W2051775752 cites W1963861214 @default.
• W2051775752 cites W1964887436 @default.
• W2051775752 cites W1965049187 @default.
• W2051775752 cites W1965485473 @default.
• W2051775752 cites W1974543288 @default.
• W2051775752 cites W1995345622 @default.
• W2051775752 cites W1996634009 @default.
• W2051775752 cites W2002258009 @default.
• W2051775752 cites W2004714646 @default.
• W2051775752 cites W2013783430 @default.
• W2051775752 cites W2014628245 @default.
• W2051775752 cites W2017984132 @default.
• W2051775752 cites W2023632245 @default.
• W2051775752 cites W2026875853 @default.
• W2051775752 cites W2027960511 @default.
• W2051775752 cites W2029927674 @default.
• W2051775752 cites W2030787175 @default.
• W2051775752 cites W2031468774 @default.
• W2051775752 cites W2034154042 @default.
• W2051775752 cites W2039492946 @default.
• W2051775752 cites W2041216529 @default.
• W2051775752 cites W2043448829 @default.
• W2051775752 cites W2053241850 @default.
• W2051775752 cites W2054034169 @default.
• W2051775752 cites W2056150433 @default.
• W2051775752 cites W2060848806 @default.
• W2051775752 cites W2066123080 @default.
• W2051775752 cites W2067552208 @default.
• W2051775752 cites W2069506489 @default.
• W2051775752 cites W2084347011 @default.
• W2051775752 cites W2089021682 @default.
• W2051775752 cites W2092279499 @default.
• W2051775752 cites W2098781795 @default.
• W2051775752 cites W2110838631 @default.
• W2051775752 cites W2117798874 @default.
• W2051775752 cites W2135732933 @default.
• W2051775752 cites W2141735242 @default.
• W2051775752 cites W2143212326 @default.
• W2051775752 cites W2147009832 @default.
• W2051775752 cites W2150166524 @default.
• W2051775752 cites W2155898968 @default.
• W2051775752 cites W2156852094 @default.
• W2051775752 cites W2157615131 @default.
• W2051775752 cites W2162331558 @default.
• W2051775752 cites W2168357995 @default.
• W2051775752 cites W2169657971 @default.
• W2051775752 cites W2169777226 @default.
• W2051775752 cites W4237410627 @default.
• W2051775752 doi "https://doi.org/10.1016/j.virol.2005.06.008" @default.
• W2051775752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15996703" @default.
• W2051775752 hasPublicationYear "2005" @default.
• W2051775752 type Work @default.
• W2051775752 sameAs 2051775752 @default.
• W2051775752 citedByCount "200" @default.
• W2051775752 countsByYear W20517757522012 @default.
• W2051775752 countsByYear W20517757522013 @default.
• W2051775752 countsByYear W20517757522014 @default.
• W2051775752 countsByYear W20517757522015 @default.
• W2051775752 countsByYear W20517757522016 @default.
• W2051775752 countsByYear W20517757522017 @default.
• W2051775752 countsByYear W20517757522018 @default.
• W2051775752 countsByYear W20517757522019 @default.
• W2051775752 countsByYear W20517757522020 @default.
• W2051775752 countsByYear W20517757522021 @default.
• W2051775752 countsByYear W20517757522022 @default.
• W2051775752 countsByYear W20517757522023 @default.
• W2051775752 crossrefType "journal-article" @default.
• W2051775752 hasAuthorship W2051775752A5004696190 @default.
• W2051775752 hasAuthorship W2051775752A5006925420 @default.
• W2051775752 hasAuthorship W2051775752A5023220693 @default.
• W2051775752 hasAuthorship W2051775752A5025375416 @default.
• W2051775752 hasAuthorship W2051775752A5047077004 @default.
• W2051775752 hasAuthorship W2051775752A5054808938 @default.
• W2051775752 hasAuthorship W2051775752A5057428201 @default.
• W2051775752 hasAuthorship W2051775752A5069302796 @default.
• W2051775752 hasAuthorship W2051775752A5088170766 @default.
• W2051775752 hasConcept C104317684 @default.
• W2051775752 hasConcept C140704245 @default.
• W2051775752 hasConcept C14430832 @default.

• next