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- W2051780187 abstract "Background: Atrial fibrillation is the most common sustained cardiac arrhythmia. Although anti-arrhythmic agents have been used for over 100 years, paradoxical arrhythmias and non-cardiac toxicity, coupled with suboptimal efficacy has limited their use, creating a gap. Current options: Safety and efficacy of commonly used anti-arrhythmic agents were reviewed, illustrating variable long-term efficacy and undesirable side-effect profiles. A newer agent, dronedarone, addressed some of the problems associated with amiodarone use but is less effective at long-term rhythm control and has been associated with increased mortality in certain patient subgroups. Conclusion: It is clear that there is still a role for older anti-arrhythmic agents and although dronedarone has taken steps to rectify safety concerns, it has done so with a lower efficacy. Promising new agents are on the horizon that aim to address these limitations and transform the way in which atrial fibrillation is managed pharmacologically." @default.
- W2051780187 created "2016-06-24" @default.
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- W2051780187 date "2015-04-02" @default.
- W2051780187 modified "2023-09-25" @default.
- W2051780187 title "The role of anti-arrhythmic drugs for AF rhythm control" @default.
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- W2051780187 doi "https://doi.org/10.12968/bjca.2015.10.4.179" @default.
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