FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051799574> ?p ?o ?g. }

• W2051799574 endingPage "8792" @default.
• W2051799574 startingPage "8784" @default.
• W2051799574 abstract "G-quadruplexes are known to be potential targets for therapeutic intervention, thus resulting in development of various quadruplex interacting ligands. However, until now, no systemic study has been performed to understand molecular recognition of quadruplex in the presence of molecular crowding agents mimicking cellular conditions. The stability and molecular recognition of quadruplex can be influenced by loop length. Herein, we attempted to study the interaction of 5,10,15,20-tetrakis(1-methyl-4-pyridyl)-21H,23H-porphine (TMPyP4), a well-known G-quadruplex binding ligand with various DNA quadruplexes differing in total loop length and loop arrangement in both the absence and presence of molecular crowding agents. Results obtained from CD studies revealed that longer loops favor mixed and antiparallel conformation in both the absence and presence of 30% ethylene glycol. UV thermal melting studies revealed that the stability and formation of quadruplex increases in the presence of 30% ethylene glycol. Moreover, the binding of TMPyP4 molecule to both of the binding sites in different quadruplexes with total loop length varying from 3 to 9 remains unchanged in both the absence and presence of 30% ethylene glycol. The binding affinity (Ka) of TMPyP4 was found to be decreased approximately by 1 order for the quadruplex sequences with total loop length varying from 11 to 15 in the presence of molecular crowding agents." @default.
• W2051799574 created "2016-06-24" @default.
• W2051799574 creator A5022524918 @default.
• W2051799574 creator A5060097336 @default.
• W2051799574 date "2009-05-29" @default.
• W2051799574 modified "2023-09-25" @default.
• W2051799574 title "Stability and Molecular Recognition of Quadruplexes with Different Loop Length in the Absence and Presence of Molecular Crowding Agents" @default.
• W2051799574 cites W1513461363 @default.
• W2051799574 cites W1594075865 @default.
• W2051799574 cites W1967319246 @default.
• W2051799574 cites W1968054603 @default.
• W2051799574 cites W1970207762 @default.
• W2051799574 cites W1975690779 @default.
• W2051799574 cites W1976334693 @default.
• W2051799574 cites W1978502771 @default.
• W2051799574 cites W1980822832 @default.
• W2051799574 cites W1981358003 @default.
• W2051799574 cites W1985907793 @default.
• W2051799574 cites W1989651677 @default.
• W2051799574 cites W1992223960 @default.
• W2051799574 cites W2003842226 @default.
• W2051799574 cites W2004787540 @default.
• W2051799574 cites W2009139426 @default.
• W2051799574 cites W2010047162 @default.
• W2051799574 cites W2011428226 @default.
• W2051799574 cites W2012834867 @default.
• W2051799574 cites W2015019742 @default.
• W2051799574 cites W2019729602 @default.
• W2051799574 cites W2020862596 @default.
• W2051799574 cites W2021003022 @default.
• W2051799574 cites W2025811126 @default.
• W2051799574 cites W2026518463 @default.
• W2051799574 cites W2028753366 @default.
• W2051799574 cites W2029988455 @default.
• W2051799574 cites W2032523990 @default.
• W2051799574 cites W2032698727 @default.
• W2051799574 cites W2033212454 @default.
• W2051799574 cites W2033786703 @default.
• W2051799574 cites W2035738941 @default.
• W2051799574 cites W2037472954 @default.
• W2051799574 cites W2038526049 @default.
• W2051799574 cites W2038606471 @default.
• W2051799574 cites W2040611074 @default.
• W2051799574 cites W2041705791 @default.
• W2051799574 cites W2041884820 @default.
• W2051799574 cites W2041894953 @default.
• W2051799574 cites W2041954922 @default.
• W2051799574 cites W2042377388 @default.
• W2051799574 cites W2044132362 @default.
• W2051799574 cites W2045051369 @default.
• W2051799574 cites W2046576035 @default.
• W2051799574 cites W2047038417 @default.
• W2051799574 cites W2050971157 @default.
• W2051799574 cites W2052193915 @default.
• W2051799574 cites W2055132246 @default.
• W2051799574 cites W2055556773 @default.
• W2051799574 cites W2055827668 @default.
• W2051799574 cites W2058236842 @default.
• W2051799574 cites W2060872711 @default.
• W2051799574 cites W2061487334 @default.
• W2051799574 cites W2063457836 @default.
• W2051799574 cites W2063794009 @default.
• W2051799574 cites W2066553910 @default.
• W2051799574 cites W2067184067 @default.
• W2051799574 cites W2072682072 @default.
• W2051799574 cites W2073722866 @default.
• W2051799574 cites W2076843089 @default.
• W2051799574 cites W2077316773 @default.
• W2051799574 cites W2080045652 @default.
• W2051799574 cites W2080661557 @default.
• W2051799574 cites W2080997010 @default.
• W2051799574 cites W2084744878 @default.
• W2051799574 cites W2085198004 @default.
• W2051799574 cites W2087380875 @default.
• W2051799574 cites W2089598395 @default.
• W2051799574 cites W2089816928 @default.
• W2051799574 cites W2092452241 @default.
• W2051799574 cites W2094915988 @default.
• W2051799574 cites W2096577501 @default.
• W2051799574 cites W2099912530 @default.
• W2051799574 cites W2100440853 @default.
• W2051799574 cites W2102734197 @default.
• W2051799574 cites W2111179083 @default.
• W2051799574 cites W2121289329 @default.
• W2051799574 cites W2123525790 @default.
• W2051799574 cites W2124146425 @default.
• W2051799574 cites W2124166350 @default.
• W2051799574 cites W2134972813 @default.
• W2051799574 cites W2143881892 @default.
• W2051799574 cites W2147700328 @default.
• W2051799574 cites W2153654013 @default.
• W2051799574 cites W2161650693 @default.
• W2051799574 cites W2166990565 @default.
• W2051799574 cites W2413251518 @default.
• W2051799574 doi "https://doi.org/10.1021/jp809486g" @default.
• W2051799574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19480441" @default.
• W2051799574 hasPublicationYear "2009" @default.
• W2051799574 type Work @default.

• next