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• W2051805504 abstract "In eukaryotes, many nuclear processes are spatially compartmentalized. Previously, we have shown that in Trypanosoma cruzi, an early-divergent eukaryote, DNA replication occurs at the nuclear periphery where chromosomes remain constrained during the S phase of the cell cycle. We followed Orc1/Cdc6, a pre-replication machinery component, and the proliferating cell nuclear antigen (PCNA), a component of replication machinery, during the cell cycle of this protozoon. We found that, at the G1 stage, Orc1/Cdc6 and PCNA are dispersed throughout the nuclear space. During the G1/S transition, Orc1/Cdc6 migrates to a region close to nuclear periphery. At the onset of S phase, PCNA is loaded onto the DNA and remains constrained close to nuclear periphery. Finally, in G2, mitosis and cytokinesis, Orc1/Cdc6 and PCNA are dispersed throughout the nuclear space. Based on these findings, we propose that DNA replication in T. cruzi is accomplished by the organization of functional machineries in a spatial-temporal manner." @default.
• W2051805504 created "2016-06-24" @default.
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• W2051805504 date "2011-03-01" @default.
• W2051805504 modified "2023-10-13" @default.
• W2051805504 title "<i>Trypanosoma cruzi</i>DNA replication includes the sequential recruitment of pre-replication and replication machineries close to nuclear periphery" @default.
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• W2051805504 doi "https://doi.org/10.4161/nucl.2.2.15134" @default.
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