Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051809968> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2051809968 endingPage "185" @default.
- W2051809968 startingPage "181" @default.
- W2051809968 abstract "Purpose of review Recent experimental data shed light on the regulation of renalase, a secreted amine oxidase, which circulates in an inactive form (prorenalase). Abnormalities in the renalase pathway are evident not only in animal models of chronic kidney disease, but also during the development of hypertension, at a time when kidney function appears normal. Recent findings Prorenalase is rapidly (30–60 s) activated by increased plasma catecholamines and systolic blood pressure. Catecholamine administration promotes the secretion of preformed renalase within 5 min. Plasma renalase is markedly reduced in patients with chronic kidney disease and end-stage renal disease, and in animal models of chronic kidney disease and salt-dependent hypertension. Rats subjected to subtotal nephrectomy develop hypertension and chronic kidney disease, and exhibit low plasma and cardiac renalase, and abnormal renalase activation. Summary The renalase pathway is a previously unrecognized mechanism for regulating circulating catecholamines, cardiac function and blood pressure. In this pathway, prorenalase is rapidly activated by increased catecholamines and converted to renalase, which in turn degrades catecholamines. Abnormalities in the renalase pathway are evident in animal models of chronic kidney disease and hypertension. Collectively, these data suggest that renalase plays a key role in the regulation of sympathetic tone, blood pressure and cardiac function." @default.
- W2051809968 created "2016-06-24" @default.
- W2051809968 creator A5009238890 @default.
- W2051809968 date "2008-03-01" @default.
- W2051809968 modified "2023-10-18" @default.
- W2051809968 title "Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease" @default.
- W2051809968 cites W1966621021 @default.
- W2051809968 cites W1973307347 @default.
- W2051809968 cites W1981327055 @default.
- W2051809968 cites W1995289894 @default.
- W2051809968 cites W2006074076 @default.
- W2051809968 cites W2026399893 @default.
- W2051809968 cites W2029785070 @default.
- W2051809968 cites W2040118102 @default.
- W2051809968 cites W2082069148 @default.
- W2051809968 cites W2086430665 @default.
- W2051809968 cites W2130985710 @default.
- W2051809968 cites W2140463015 @default.
- W2051809968 cites W2145632027 @default.
- W2051809968 cites W2146918609 @default.
- W2051809968 cites W2164930059 @default.
- W2051809968 doi "https://doi.org/10.1097/mnh.0b013e3282f521ba" @default.
- W2051809968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18277152" @default.
- W2051809968 hasPublicationYear "2008" @default.
- W2051809968 type Work @default.
- W2051809968 sameAs 2051809968 @default.
- W2051809968 citedByCount "73" @default.
- W2051809968 countsByYear W20518099682012 @default.
- W2051809968 countsByYear W20518099682013 @default.
- W2051809968 countsByYear W20518099682014 @default.
- W2051809968 countsByYear W20518099682015 @default.
- W2051809968 countsByYear W20518099682016 @default.
- W2051809968 countsByYear W20518099682017 @default.
- W2051809968 countsByYear W20518099682018 @default.
- W2051809968 countsByYear W20518099682019 @default.
- W2051809968 countsByYear W20518099682020 @default.
- W2051809968 countsByYear W20518099682021 @default.
- W2051809968 countsByYear W20518099682022 @default.
- W2051809968 countsByYear W20518099682023 @default.
- W2051809968 crossrefType "journal-article" @default.
- W2051809968 hasAuthorship W2051809968A5009238890 @default.
- W2051809968 hasConcept C126322002 @default.
- W2051809968 hasConcept C134018914 @default.
- W2051809968 hasConcept C159641895 @default.
- W2051809968 hasConcept C2778514916 @default.
- W2051809968 hasConcept C2778653478 @default.
- W2051809968 hasConcept C2779134260 @default.
- W2051809968 hasConcept C2780091579 @default.
- W2051809968 hasConcept C513476851 @default.
- W2051809968 hasConcept C57190642 @default.
- W2051809968 hasConcept C71924100 @default.
- W2051809968 hasConcept C84393581 @default.
- W2051809968 hasConceptScore W2051809968C126322002 @default.
- W2051809968 hasConceptScore W2051809968C134018914 @default.
- W2051809968 hasConceptScore W2051809968C159641895 @default.
- W2051809968 hasConceptScore W2051809968C2778514916 @default.
- W2051809968 hasConceptScore W2051809968C2778653478 @default.
- W2051809968 hasConceptScore W2051809968C2779134260 @default.
- W2051809968 hasConceptScore W2051809968C2780091579 @default.
- W2051809968 hasConceptScore W2051809968C513476851 @default.
- W2051809968 hasConceptScore W2051809968C57190642 @default.
- W2051809968 hasConceptScore W2051809968C71924100 @default.
- W2051809968 hasConceptScore W2051809968C84393581 @default.
- W2051809968 hasIssue "2" @default.
- W2051809968 hasLocation W20518099681 @default.
- W2051809968 hasLocation W20518099682 @default.
- W2051809968 hasOpenAccess W2051809968 @default.
- W2051809968 hasPrimaryLocation W20518099681 @default.
- W2051809968 hasRelatedWork W1973095062 @default.
- W2051809968 hasRelatedWork W1997653766 @default.
- W2051809968 hasRelatedWork W2006923825 @default.
- W2051809968 hasRelatedWork W2029739536 @default.
- W2051809968 hasRelatedWork W2042033030 @default.
- W2051809968 hasRelatedWork W2044985824 @default.
- W2051809968 hasRelatedWork W2127085070 @default.
- W2051809968 hasRelatedWork W2166688422 @default.
- W2051809968 hasRelatedWork W2324925659 @default.
- W2051809968 hasRelatedWork W2400445066 @default.
- W2051809968 hasVolume "17" @default.
- W2051809968 isParatext "false" @default.
- W2051809968 isRetracted "false" @default.
- W2051809968 magId "2051809968" @default.
- W2051809968 workType "article" @default.