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• W2051814878 abstract "SUMMARY Aims To test the safety and effectiveness of carboxyl‐methyl‐cellulose dressing (Aquacel TM ; ConvaTec, UK) in the management of deep diabetic foot ulcers, a group of consecutive out‐patients attending the foot clinic of the Department of Metabolic Diseases was studied. Methods Patients were selected according to the following inclusion criteria: a foot ulcer deeper than 1 cm for > 3 weeks, good peripheral blood supply (palpable peripheral pulses or ABPI > 0.9). Exclusion criteria were as follows: active infection, as evident from clinical signs (purulent discharge, redness, swelling, tenderness) and confirmed by culture exams, plasma creatinine > 2 mg/dl, recent episodes of ketoacidosis, malignancies, and any therapy or pathology which might interfere with the healing process. Twenty patients were enrolled in the study and having obtained their informed consent, their lesions were surgically debrided with the complete elimination of all necrotic tissue and debris up to the bleeding healthy tissue; then ulcers were staged and measured, and patients were randomly assigned to two different treatment groups. Patients in group A were dressed with saline‐moistened gauze, while patients in group B were dressed with Aquacel TM according to the manufacturer's instructions. All patients in both groups received special post‐operative shoes (Podiabetes; Zeno Buratto, Treviso, Italy) and crutches until complete re‐epithelialization. Ulcers were all left to heal by secondary intent. After 8 weeks patients were blindly evaluated for: the rate of reduction of lesional volume (RLV), rate of granulation tissue (GT), number of infective complications (IC). Intralesional (ILTC) and perilesional (PLTC) temperatures were also recorded with a thermocouple surface digital thermometer, and the difference between the two values (ΔTC) was calculated. Healing time (HT, days), was then compared between the two groups. Data were compared by analysis of variance ( anova ), linear regression, Kaplan–Meier survival analysis and Fisher's exact test. Results HT was significantly shorter in Group B than in Group A ( P < 0.001). RLV was significantly ( P < 0.01) higher in Group B patients compared with Group A, as well as GT ( P < 0.05). IC were in 1/10 Group B and in 3/10 Group A ( P = 0.582). In addition, both ILTC and ΔTC were higher in Group B compared with Group A ones ( P < 0.01). Conclusions Carboxyl‐methyl‐cellulose dressings were shown to be safe, effective and well tolerated in the management of non‐ischaemic, non‐infected deep diabetic foot ulcers." @default.
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• W2051814878 date "2001-04-01" @default.
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• W2051814878 title "Sodium carboxyl-methyl-cellulose dressings in the management of deep ulcerations of diabetic foot" @default.
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• W2051814878 doi "https://doi.org/10.1046/j.1464-5491.2001.00466.x" @default.
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