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- W2051815061 abstract "Individual nucleic acid molecules might be sequenced by the identification of nucleoside 5'-monophosphates as they are released by processive exonucleases. Here, we show that single molecule detection with a modified protein nanopore can be used to identify ribonucleoside and 2'-deoxyribonucleoside 5'-monophosphates, thereby taking a step along this path. Distinct levels of current block are observed for each of the four members of a set of nucleoside 5'-monophosphates when the molecules bind within a mutant alpha-hemolysin pore, (M113R)(7), equipped with the molecular adapter heptakis-(6-deoxy-6-amino)-beta-cyclodextrin. While our results compare favorably with alternative approaches, further work will be required to improve the accuracy of identification of the nucleic acid bases, to feed each released nucleotide into the pore, and to ensure that every nucleotide is captured by the adapter." @default.
- W2051815061 created "2016-06-24" @default.
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- W2051815061 date "2006-01-12" @default.
- W2051815061 modified "2023-10-16" @default.
- W2051815061 title "Toward Single Molecule DNA Sequencing: Direct Identification of Ribonucleoside and Deoxyribonucleoside 5‘-Monophosphates by Using an Engineered Protein Nanopore Equipped with a Molecular Adapter" @default.
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- W2051815061 doi "https://doi.org/10.1021/ja057123+" @default.
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