Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051818058> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2051818058 endingPage "164" @default.
- W2051818058 startingPage "161" @default.
- W2051818058 abstract "Cold ischaemia-reperfusion injuries are an unavoidable feature of current liver transplantation procedures. Damage to liver grafts accures mainly from hypothermic storage under hypoxic conditions (cold ischaemia), from sustained ischaemia during implantation into the recipient (rewarming ischaemia) and from restoration of blood and oxygen to the graft (reperfusion injury). These three stages are characterized by progressive deteriorations in hepatic function, with sinusoidal endothelial cells most affected during cold ischaemia. Activation of Kupffer cells (hepatic macrophages) at reperfusion augments damage to both endothelial and parenchymal cells by the release of numerous compounds which initiate and perpetrate injury and impair the hepatic microcirculation. The key events in the expression of ischaemia-reperfusion injury are detailed and therapeutic interventions are described which target these steps. The treatments discussed include University of Wisconsin (UW) preservation solution, calcium channel blockade, inhibitors of Kupffer cell activation, promoters of microvascular vasodilation, hepatoprotectants and the use of anti-oxidants." @default.
- W2051818058 created "2016-06-24" @default.
- W2051818058 creator A5075887616 @default.
- W2051818058 date "1998-01-01" @default.
- W2051818058 modified "2023-10-16" @default.
- W2051818058 title "Ischaemia-reperfusion injury of the liver: treatment in theory and in practice" @default.
- W2051818058 cites W1581985671 @default.
- W2051818058 cites W1821918060 @default.
- W2051818058 cites W1981363079 @default.
- W2051818058 cites W1983871786 @default.
- W2051818058 cites W2006687037 @default.
- W2051818058 cites W2009651773 @default.
- W2051818058 cites W2019480457 @default.
- W2051818058 cites W2019489158 @default.
- W2051818058 cites W2024884563 @default.
- W2051818058 cites W2029604533 @default.
- W2051818058 cites W2033889537 @default.
- W2051818058 cites W2034798408 @default.
- W2051818058 cites W2061340886 @default.
- W2051818058 cites W2064329624 @default.
- W2051818058 cites W2064517350 @default.
- W2051818058 cites W2068144001 @default.
- W2051818058 cites W2087171263 @default.
- W2051818058 cites W2119030223 @default.
- W2051818058 cites W2142749828 @default.
- W2051818058 cites W2148907788 @default.
- W2051818058 cites W2156294614 @default.
- W2051818058 doi "https://doi.org/10.1002/biof.5520080127" @default.
- W2051818058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9699026" @default.
- W2051818058 hasPublicationYear "1998" @default.
- W2051818058 type Work @default.
- W2051818058 sameAs 2051818058 @default.
- W2051818058 citedByCount "11" @default.
- W2051818058 countsByYear W20518180582014 @default.
- W2051818058 countsByYear W20518180582018 @default.
- W2051818058 countsByYear W20518180582021 @default.
- W2051818058 crossrefType "journal-article" @default.
- W2051818058 hasAuthorship W2051818058A5075887616 @default.
- W2051818058 hasConcept C113278225 @default.
- W2051818058 hasConcept C120770815 @default.
- W2051818058 hasConcept C123012128 @default.
- W2051818058 hasConcept C126322002 @default.
- W2051818058 hasConcept C12722491 @default.
- W2051818058 hasConcept C164705383 @default.
- W2051818058 hasConcept C170493617 @default.
- W2051818058 hasConcept C202751555 @default.
- W2051818058 hasConcept C2778468042 @default.
- W2051818058 hasConcept C2779609443 @default.
- W2051818058 hasConcept C2780114680 @default.
- W2051818058 hasConcept C2911091166 @default.
- W2051818058 hasConcept C541997718 @default.
- W2051818058 hasConcept C55493867 @default.
- W2051818058 hasConcept C71924100 @default.
- W2051818058 hasConcept C86803240 @default.
- W2051818058 hasConcept C98274493 @default.
- W2051818058 hasConceptScore W2051818058C113278225 @default.
- W2051818058 hasConceptScore W2051818058C120770815 @default.
- W2051818058 hasConceptScore W2051818058C123012128 @default.
- W2051818058 hasConceptScore W2051818058C126322002 @default.
- W2051818058 hasConceptScore W2051818058C12722491 @default.
- W2051818058 hasConceptScore W2051818058C164705383 @default.
- W2051818058 hasConceptScore W2051818058C170493617 @default.
- W2051818058 hasConceptScore W2051818058C202751555 @default.
- W2051818058 hasConceptScore W2051818058C2778468042 @default.
- W2051818058 hasConceptScore W2051818058C2779609443 @default.
- W2051818058 hasConceptScore W2051818058C2780114680 @default.
- W2051818058 hasConceptScore W2051818058C2911091166 @default.
- W2051818058 hasConceptScore W2051818058C541997718 @default.
- W2051818058 hasConceptScore W2051818058C55493867 @default.
- W2051818058 hasConceptScore W2051818058C71924100 @default.
- W2051818058 hasConceptScore W2051818058C86803240 @default.
- W2051818058 hasConceptScore W2051818058C98274493 @default.
- W2051818058 hasIssue "1-2" @default.
- W2051818058 hasLocation W20518180581 @default.
- W2051818058 hasLocation W20518180582 @default.
- W2051818058 hasOpenAccess W2051818058 @default.
- W2051818058 hasPrimaryLocation W20518180581 @default.
- W2051818058 hasRelatedWork W2014193194 @default.
- W2051818058 hasRelatedWork W2051818058 @default.
- W2051818058 hasRelatedWork W2116134279 @default.
- W2051818058 hasRelatedWork W2137701361 @default.
- W2051818058 hasRelatedWork W2146119535 @default.
- W2051818058 hasRelatedWork W2285906990 @default.
- W2051818058 hasRelatedWork W2347759412 @default.
- W2051818058 hasRelatedWork W2388310718 @default.
- W2051818058 hasRelatedWork W2389675360 @default.
- W2051818058 hasRelatedWork W2412477048 @default.
- W2051818058 hasVolume "8" @default.
- W2051818058 isParatext "false" @default.
- W2051818058 isRetracted "false" @default.
- W2051818058 magId "2051818058" @default.
- W2051818058 workType "article" @default.