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- W2051837145 abstract "Patients with primary glioblastoma (GBM) have a dismal prognosis despite standard therapy, which can induce potentially deleterious side effects. Arming the immune system is an alternative therapeutic approach, as its cellular effectors and inherent capacity for memory can be utilized to specifically target invasive tumor cells, while sparing collateral damage to otherwise healthy brain parenchyma.Active immunotherapy is aimed at eliciting a specific immune response against tumor antigens. Dendritic cells (DCs) are one of the most potent activators of de novo and recall immune responses and are thus a vehicle for successful immunotherapy. Currently, investigators are optimizing DC vaccines by enhancing maturation status and migratory potential to induce more potent antitumor responses. An update on the most recent DC immunotherapy trials is provided.Targeting of unique antigens restricted to the tumor itself is the most important parameter in advancing DC vaccines. In order to overcome intrinsic mechanisms of immune evasion observed in GBM, the future of DC-based therapy lies in a multi-antigenic vaccine approach. Successful targeting of multiple antigens will require a comprehensive understanding of all immunologically relevant oncological epitopes present in each tumor, thereby permitting a rational vaccine design." @default.
- W2051837145 created "2016-06-24" @default.
- W2051837145 creator A5022720964 @default.
- W2051837145 creator A5023812958 @default.
- W2051837145 creator A5037596103 @default.
- W2051837145 date "2014-10-18" @default.
- W2051837145 modified "2023-09-25" @default.
- W2051837145 title "Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma" @default.
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- W2051837145 doi "https://doi.org/10.1517/14712598.2015.972361" @default.