Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051844708> ?p ?o ?g. }
- W2051844708 endingPage "7999" @default.
- W2051844708 startingPage "7986" @default.
- W2051844708 abstract "We report the synthesis of new compounds 4–35 based on structural modifications of different moieties of previously described lead UCM-2550. The new nonpiperazine derivatives, representing second-generation agonists, were assessed for binding affinity, selectivity, and functional activity at the 5-HT1A receptor (5-HT1AR). Computational β2-based homology models of the ligand–receptor complexes were used to explain the observed structure–affinity relationships. Selected candidates were also evaluated for their potential in vitro and in vivo neuroprotective properties. Interestingly, compound 26 (2-{6-[(3,4-dihydro-2H-chromen-2-ylmethyl)amino]hexyl}tetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione) has been characterized as a high-affinity and potent 5-HT1AR agonist (Ki = 5.9 nM, EC50 = 21.8 nM) and exhibits neuroprotective effect in neurotoxicity assays in primary cell cultures from rat hippocampus and in the MCAO model of focal cerebral ischemia in rats." @default.
- W2051844708 created "2016-06-24" @default.
- W2051844708 creator A5003865748 @default.
- W2051844708 creator A5022809373 @default.
- W2051844708 creator A5022975855 @default.
- W2051844708 creator A5040621617 @default.
- W2051844708 creator A5046444163 @default.
- W2051844708 creator A5047334492 @default.
- W2051844708 creator A5052627041 @default.
- W2051844708 creator A5057736472 @default.
- W2051844708 creator A5069868485 @default.
- W2051844708 creator A5073222983 @default.
- W2051844708 creator A5073488277 @default.
- W2051844708 creator A5078484971 @default.
- W2051844708 creator A5090394808 @default.
- W2051844708 date "2011-11-11" @default.
- W2051844708 modified "2023-10-18" @default.
- W2051844708 title "New Serotonin 5-HT<sub>1A</sub> Receptor Agonists with Neuroprotective Effect against Ischemic Cell Damage" @default.
- W2051844708 cites W1502702211 @default.
- W2051844708 cites W1506946474 @default.
- W2051844708 cites W1510378627 @default.
- W2051844708 cites W1546400389 @default.
- W2051844708 cites W1552728282 @default.
- W2051844708 cites W1908561802 @default.
- W2051844708 cites W1963786800 @default.
- W2051844708 cites W1965006436 @default.
- W2051844708 cites W1968912840 @default.
- W2051844708 cites W1978057735 @default.
- W2051844708 cites W1978392092 @default.
- W2051844708 cites W1982957526 @default.
- W2051844708 cites W1988097700 @default.
- W2051844708 cites W1989523265 @default.
- W2051844708 cites W1991339455 @default.
- W2051844708 cites W1994932901 @default.
- W2051844708 cites W1995897765 @default.
- W2051844708 cites W2000698995 @default.
- W2051844708 cites W2000942012 @default.
- W2051844708 cites W2011350799 @default.
- W2051844708 cites W2013523373 @default.
- W2051844708 cites W2018760466 @default.
- W2051844708 cites W2020601776 @default.
- W2051844708 cites W2023219634 @default.
- W2051844708 cites W2028178119 @default.
- W2051844708 cites W2028645925 @default.
- W2051844708 cites W2034973230 @default.
- W2051844708 cites W2036743679 @default.
- W2051844708 cites W2044908277 @default.
- W2051844708 cites W2050596412 @default.
- W2051844708 cites W2053074524 @default.
- W2051844708 cites W2054526986 @default.
- W2051844708 cites W2056395878 @default.
- W2051844708 cites W2058948595 @default.
- W2051844708 cites W2059197789 @default.
- W2051844708 cites W2063643899 @default.
- W2051844708 cites W2071485618 @default.
- W2051844708 cites W2072442323 @default.
- W2051844708 cites W2074631079 @default.
- W2051844708 cites W2075434858 @default.
- W2051844708 cites W2076658046 @default.
- W2051844708 cites W2079680681 @default.
- W2051844708 cites W2080231167 @default.
- W2051844708 cites W2083458445 @default.
- W2051844708 cites W2088802774 @default.
- W2051844708 cites W2094125056 @default.
- W2051844708 cites W2095114193 @default.
- W2051844708 cites W2100861559 @default.
- W2051844708 cites W2104961861 @default.
- W2051844708 cites W2114520383 @default.
- W2051844708 cites W2114880081 @default.
- W2051844708 cites W2121487119 @default.
- W2051844708 cites W2127739127 @default.
- W2051844708 cites W2130322124 @default.
- W2051844708 cites W2130423340 @default.
- W2051844708 cites W2130894897 @default.
- W2051844708 cites W2144470004 @default.
- W2051844708 cites W2144904732 @default.
- W2051844708 cites W2149861914 @default.
- W2051844708 cites W2149918176 @default.
- W2051844708 cites W2157177243 @default.
- W2051844708 cites W2157558738 @default.
- W2051844708 cites W2168966210 @default.
- W2051844708 cites W2315784694 @default.
- W2051844708 cites W2322113032 @default.
- W2051844708 cites W2332199617 @default.
- W2051844708 cites W2950963447 @default.
- W2051844708 cites W2950967766 @default.
- W2051844708 cites W2953392165 @default.
- W2051844708 cites W4211248987 @default.
- W2051844708 doi "https://doi.org/10.1021/jm2007886" @default.
- W2051844708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22029386" @default.
- W2051844708 hasPublicationYear "2011" @default.
- W2051844708 type Work @default.
- W2051844708 sameAs 2051844708 @default.
- W2051844708 citedByCount "35" @default.
- W2051844708 countsByYear W20518447082012 @default.
- W2051844708 countsByYear W20518447082013 @default.
- W2051844708 countsByYear W20518447082014 @default.
- W2051844708 countsByYear W20518447082015 @default.