FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051860428> ?p ?o ?g. }

• W2051860428 endingPage "2051" @default.
• W2051860428 startingPage "2050" @default.
• W2051860428 abstract "Benedetto Falsini and Silvia Bisti remind us of the current understanding of pathogenic mechanisms underlying Stargardt's disease and atrophic age-related macular degeneration (AMD), and suggest that transplanted retinal pigment epithelium derived from human embryonic stem cells (hESC) will not overcome these underlying mechanisms. In fact, we postulated that, if the treatment under study were to be proven safe and effective, “new” retinal pigment epithelium would theoretically confer decades of protection against these pathological mechanisms. For example, in patients with Stargardt's disease, visual loss is commonly identified in the second or third decade of life, although the ABCA4 malfunction is present from birth. Similarly, the mechanisms underlying AMD take five to eight decades to adversely affect retinal pigment epithelium. Another way to look at this is that we are studying a treatment for an unmet medical need, and not necessarily a cure. However, we agree in principle with Falsini and Bisti that future stem-cell therapies might in some instances be combined with pharmacological therapies. We wish to clarify some points in response to Jinhai Huang and colleagues. At no point in our paper do we claim evidence of a therapeutic response to the transplantation of hESC-derived retinal pigment epithelium into our two patients. The report focuses on preliminary safety findings. Functional improvements seen in our patients are qualified as very difficult to measure and as perhaps being due to other factors, including the placebo effect. Measurement of visual improvement in patients with very low vision is difficult. Consensus on the best methods for measuring vision in such patients has not been reached. We appreciate the suggestion to consider the Berkeley Rudimentary Vision Test as a clinical research tool. However, we are hopeful that if our strategy proves safe, we might migrate to studying patients with earlier-stage disease and better visual acuities, thus obviating the stated challenges while theoretically improving the chances for meaningful visual improvements. Huang and colleagues are correct that multifocal electroretinographic data are being collected as part of our protocol. However, at this point, without reliable fixation and tracking technology, these studies are impossible to interpret. Our strategy in translating stem-cell therapies towards clinical use involves a step-by-step approach, asking one scientific and regulatory question at a time. In this instance, we report on preliminary safety findings in the first two patients at 4 months after transplantation. We agree with regulatory agencies such as the US Food and Drug Administration that only one variable should be studied at a time. In our opinion, this strategy holds particularly true when dealing with complex biological therapeutic agents such as stem cells. RL is an employee of Advanced Cell Technology—a biotechnology company in the area of stem cells and regenerative medicine. The other authors declare that they have no conflicts of interest. Embryonic stem-cell-derived retinal pigment epithelial cells for macular degenerationSteven Schwartz and colleagues' study on transplantation of retinal pigment epithelium derived from human embryonic stem cells (hESCs) for the treatment of macular degeneration (Feb 25, p 713)1 is an important step towards treatment of such disorders. We believe, however, that a basic issue regarding the rationale of this approach should be addressed. Full-Text PDF Embryonic stem-cell-derived retinal pigment epithelial cells for macular degenerationThe results of the preliminary trial by Steven Schwartz and colleagues1 add to the evidence from in-vitro and animal studies in suggesting that transplantation of retinal pigment epithelium derived from human embryonic stem cells could be used to treat macular degeneration. The question remains whether Schwartz and colleagues' two human cases can be taken to illustrate a therapeutic response. The outcome measures used were anatomical appearance, visual acuity, and subjective response. Full-Text PDF" @default.
• W2051860428 created "2016-06-24" @default.
• W2051860428 creator A5025464234 @default.
• W2051860428 creator A5059786776 @default.
• W2051860428 creator A5067457055 @default.
• W2051860428 creator A5079231031 @default.
• W2051860428 creator A5086738829 @default.
• W2051860428 date "2012-06-01" @default.
• W2051860428 modified "2023-09-27" @default.
• W2051860428 title "Embryonic stem-cell-derived retinal pigment epithelial cells for macular degeneration – Authors' reply" @default.
• W2051860428 doi "https://doi.org/10.1016/s0140-6736(12)60892-7" @default.
• W2051860428 hasPublicationYear "2012" @default.
• W2051860428 type Work @default.
• W2051860428 sameAs 2051860428 @default.
• W2051860428 citedByCount "2" @default.
• W2051860428 countsByYear W20518604282020 @default.
• W2051860428 crossrefType "journal-article" @default.
• W2051860428 hasAuthorship W2051860428A5025464234 @default.
• W2051860428 hasAuthorship W2051860428A5059786776 @default.
• W2051860428 hasAuthorship W2051860428A5067457055 @default.
• W2051860428 hasAuthorship W2051860428A5079231031 @default.
• W2051860428 hasAuthorship W2051860428A5086738829 @default.
• W2051860428 hasBestOaLocation W20518604281 @default.
• W2051860428 hasConcept C104317684 @default.
• W2051860428 hasConcept C118487528 @default.
• W2051860428 hasConcept C127716648 @default.
• W2051860428 hasConcept C141071460 @default.
• W2051860428 hasConcept C142724271 @default.
• W2051860428 hasConcept C145103041 @default.
• W2051860428 hasConcept C169760540 @default.
• W2051860428 hasConcept C2776403814 @default.
• W2051860428 hasConcept C2777093970 @default.
• W2051860428 hasConcept C2778024200 @default.
• W2051860428 hasConcept C2778376644 @default.
• W2051860428 hasConcept C2779134260 @default.
• W2051860428 hasConcept C2779234561 @default.
• W2051860428 hasConcept C2779460726 @default.
• W2051860428 hasConcept C2779918416 @default.
• W2051860428 hasConcept C2780604041 @default.
• W2051860428 hasConcept C2780827179 @default.
• W2051860428 hasConcept C28328180 @default.
• W2051860428 hasConcept C2911091166 @default.
• W2051860428 hasConcept C54355233 @default.
• W2051860428 hasConcept C55493867 @default.
• W2051860428 hasConcept C71924100 @default.
• W2051860428 hasConcept C86803240 @default.
• W2051860428 hasConcept C95444343 @default.
• W2051860428 hasConceptScore W2051860428C104317684 @default.
• W2051860428 hasConceptScore W2051860428C118487528 @default.
• W2051860428 hasConceptScore W2051860428C127716648 @default.
• W2051860428 hasConceptScore W2051860428C141071460 @default.
• W2051860428 hasConceptScore W2051860428C142724271 @default.
• W2051860428 hasConceptScore W2051860428C145103041 @default.
• W2051860428 hasConceptScore W2051860428C169760540 @default.
• W2051860428 hasConceptScore W2051860428C2776403814 @default.
• W2051860428 hasConceptScore W2051860428C2777093970 @default.
• W2051860428 hasConceptScore W2051860428C2778024200 @default.
• W2051860428 hasConceptScore W2051860428C2778376644 @default.
• W2051860428 hasConceptScore W2051860428C2779134260 @default.
• W2051860428 hasConceptScore W2051860428C2779234561 @default.
• W2051860428 hasConceptScore W2051860428C2779460726 @default.
• W2051860428 hasConceptScore W2051860428C2779918416 @default.
• W2051860428 hasConceptScore W2051860428C2780604041 @default.
• W2051860428 hasConceptScore W2051860428C2780827179 @default.
• W2051860428 hasConceptScore W2051860428C28328180 @default.
• W2051860428 hasConceptScore W2051860428C2911091166 @default.
• W2051860428 hasConceptScore W2051860428C54355233 @default.
• W2051860428 hasConceptScore W2051860428C55493867 @default.
• W2051860428 hasConceptScore W2051860428C71924100 @default.
• W2051860428 hasConceptScore W2051860428C86803240 @default.
• W2051860428 hasConceptScore W2051860428C95444343 @default.
• W2051860428 hasIssue "9831" @default.
• W2051860428 hasLocation W20518604281 @default.
• W2051860428 hasOpenAccess W2051860428 @default.
• W2051860428 hasPrimaryLocation W20518604281 @default.
• W2051860428 hasRelatedWork W1721144965 @default.
• W2051860428 hasRelatedWork W2002437061 @default.
• W2051860428 hasRelatedWork W2051860428 @default.
• W2051860428 hasRelatedWork W2103376560 @default.
• W2051860428 hasRelatedWork W2105983899 @default.
• W2051860428 hasRelatedWork W2259914024 @default.
• W2051860428 hasRelatedWork W2811483200 @default.
• W2051860428 hasRelatedWork W2900433461 @default.
• W2051860428 hasRelatedWork W3085761024 @default.
• W2051860428 hasRelatedWork W4366352725 @default.
• W2051860428 hasVolume "379" @default.
• W2051860428 isParatext "false" @default.
• W2051860428 isRetracted "false" @default.
• W2051860428 magId "2051860428" @default.
• W2051860428 workType "article" @default.