FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051877077> ?p ?o ?g. }

• W2051877077 endingPage "525" @default.
• W2051877077 startingPage "521" @default.
• W2051877077 abstract "The action of adenosine-5′-O-(2-thiodiphosphate), a non-hydrolysable purine analogue and potent P2Y1-purinoceptor agonist, was studied on immediate early gene expression in rat astrocyte cultures. A rapid and transient increase in c-fos, junB, c-jun and Tis11 messenger RNA was observed in cultured astrocytes after treatment with adenosine-5′-O-(2-thiodiphosphate). Maximal induction of immediate early gene expression was obtained within 30 min of stimulation and c-fos was the most sensitive indicator of P2Y-purinoceptor activation. Calcitonin gene-related peptide has also been shown to be a potent inducer of c-fos messenger RNA in cultured astroglial cells. The combined stimulation of astrocytes with calcitonin gene-related peptide and adenosine-5′-O-(2-thiodiphosphate) resulted in the potentiated expression of c-fos messenger RNA. The superinduction of immediate early gene expression by calcitonin gene-related peptide and extracellular ATP in cultured astrocytes might result from intracellular signal transduction cross-talk, since adenosine-5′-O-(2-thiodiphosphate) was found to increase calcitonin gene-related peptide-induced cyclic AMP accumulation by 35%. Phorbol 12-myristate 13-acetate also increased calcitonin gene-related peptide-evoked cyclic AMP accumulation and led to the induction of immediate early gene expression, suggesting that protein kinase C might be at least in part involved in purinergic cross-talk. Our results demonstrate synergistic roles for extracellular ATP and calcitonin gene-related peptide in the transcriptional activation of astroglial cells." @default.
• W2051877077 created "2016-06-24" @default.
• W2051877077 creator A5055109212 @default.
• W2051877077 creator A5058985135 @default.
• W2051877077 creator A5074463674 @default.
• W2051877077 creator A5082018475 @default.
• W2051877077 date "1998-04-01" @default.
• W2051877077 modified "2023-10-10" @default.
• W2051877077 title "Stimulation of P2Y-purinoceptors on astrocytes results in immediate early gene expression and potentiation of neuropeptide action" @default.
• W2051877077 cites W1483800737 @default.
• W2051877077 cites W1521158172 @default.
• W2051877077 cites W1557611662 @default.
• W2051877077 cites W1931904633 @default.
• W2051877077 cites W1947888345 @default.
• W2051877077 cites W1967578536 @default.
• W2051877077 cites W1968700446 @default.
• W2051877077 cites W1972195320 @default.
• W2051877077 cites W1995536774 @default.
• W2051877077 cites W1997118739 @default.
• W2051877077 cites W2003293902 @default.
• W2051877077 cites W2005739111 @default.
• W2051877077 cites W2007284527 @default.
• W2051877077 cites W2019070413 @default.
• W2051877077 cites W2030027127 @default.
• W2051877077 cites W2035581625 @default.
• W2051877077 cites W2040409475 @default.
• W2051877077 cites W2044581359 @default.
• W2051877077 cites W2045067703 @default.
• W2051877077 cites W2108541860 @default.
• W2051877077 cites W2115736681 @default.
• W2051877077 cites W2129399005 @default.
• W2051877077 cites W2145130036 @default.
• W2051877077 cites W2163519888 @default.
• W2051877077 cites W2170854858 @default.
• W2051877077 cites W4300577462 @default.
• W2051877077 doi "https://doi.org/10.1016/s0306-4522(97)00653-2" @default.
• W2051877077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9622249" @default.
• W2051877077 hasPublicationYear "1998" @default.
• W2051877077 type Work @default.
• W2051877077 sameAs 2051877077 @default.
• W2051877077 citedByCount "40" @default.
• W2051877077 countsByYear W20518770772012 @default.
• W2051877077 countsByYear W20518770772013 @default.
• W2051877077 countsByYear W20518770772014 @default.
• W2051877077 countsByYear W20518770772015 @default.
• W2051877077 countsByYear W20518770772016 @default.
• W2051877077 countsByYear W20518770772019 @default.
• W2051877077 countsByYear W20518770772022 @default.
• W2051877077 countsByYear W20518770772023 @default.
• W2051877077 crossrefType "journal-article" @default.
• W2051877077 hasAuthorship W2051877077A5055109212 @default.
• W2051877077 hasAuthorship W2051877077A5058985135 @default.
• W2051877077 hasAuthorship W2051877077A5074463674 @default.
• W2051877077 hasAuthorship W2051877077A5082018475 @default.
• W2051877077 hasConcept C104317684 @default.
• W2051877077 hasConcept C118303440 @default.
• W2051877077 hasConcept C126322002 @default.
• W2051877077 hasConcept C134018914 @default.
• W2051877077 hasConcept C150194340 @default.
• W2051877077 hasConcept C153911025 @default.
• W2051877077 hasConcept C163170386 @default.
• W2051877077 hasConcept C163235415 @default.
• W2051877077 hasConcept C170493617 @default.
• W2051877077 hasConcept C24998067 @default.
• W2051877077 hasConcept C2776991684 @default.
• W2051877077 hasConcept C2777542381 @default.
• W2051877077 hasConcept C2779555244 @default.
• W2051877077 hasConcept C529278444 @default.
• W2051877077 hasConcept C55493867 @default.
• W2051877077 hasConcept C62478195 @default.
• W2051877077 hasConcept C71924100 @default.
• W2051877077 hasConcept C86803240 @default.
• W2051877077 hasConcept C95444343 @default.
• W2051877077 hasConceptScore W2051877077C104317684 @default.
• W2051877077 hasConceptScore W2051877077C118303440 @default.
• W2051877077 hasConceptScore W2051877077C126322002 @default.
• W2051877077 hasConceptScore W2051877077C134018914 @default.
• W2051877077 hasConceptScore W2051877077C150194340 @default.
• W2051877077 hasConceptScore W2051877077C153911025 @default.
• W2051877077 hasConceptScore W2051877077C163170386 @default.
• W2051877077 hasConceptScore W2051877077C163235415 @default.
• W2051877077 hasConceptScore W2051877077C170493617 @default.
• W2051877077 hasConceptScore W2051877077C24998067 @default.
• W2051877077 hasConceptScore W2051877077C2776991684 @default.
• W2051877077 hasConceptScore W2051877077C2777542381 @default.
• W2051877077 hasConceptScore W2051877077C2779555244 @default.
• W2051877077 hasConceptScore W2051877077C529278444 @default.
• W2051877077 hasConceptScore W2051877077C55493867 @default.
• W2051877077 hasConceptScore W2051877077C62478195 @default.
• W2051877077 hasConceptScore W2051877077C71924100 @default.
• W2051877077 hasConceptScore W2051877077C86803240 @default.
• W2051877077 hasConceptScore W2051877077C95444343 @default.
• W2051877077 hasIssue "2" @default.
• W2051877077 hasLocation W20518770771 @default.
• W2051877077 hasLocation W20518770772 @default.
• W2051877077 hasOpenAccess W2051877077 @default.
• W2051877077 hasPrimaryLocation W20518770771 @default.
• W2051877077 hasRelatedWork W1618176959 @default.

• next