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• W2051879966 abstract "TCR-induced NF-kappa B activation is necessary for the innate immune response and involves induced lipid raft recruitment of the I kappa B kinase (IKK) complex. In this study, we systematically investigated lipid raft recruitment of members of the NF-kappa B activation pathway in human T cells. All upstream components leading to IKK activation were found constitutively or inducibly in lipid rafts, while the NF-kappa B/I kappa B complex and phosphorylated forms of IKK alpha/beta, I kappa B alpha and p65 are exclusively found in the cytosolic fraction. Disruption of raft organization precluded NF-kappaB activation induced by T cell costimulation, but IL-1-triggered NF-kappa B activation remained unaffected. Targeting of the IKK complex to lipid rafts caused constitutive IKK activation and NF-kappa B DNA binding, which was further triggered upon T cell costimulation. Various experimental approaches revealed that costimulation-induced IKK alpha/beta activation loop phosphorylation is independent from IKK beta-mediated transautophosphorylation, but rather involves phosphorylation by the IKK-interacting protein NIK and its upstream activator COT." @default.
• W2051879966 created "2016-06-24" @default.
• W2051879966 creator A5011893681 @default.
• W2051879966 creator A5038809023 @default.
• W2051879966 creator A5084139318 @default.
• W2051879966 date "2004-12-16" @default.
• W2051879966 modified "2023-10-11" @default.
• W2051879966 title "T?cell receptor-induced lipid raft recruitment of the I?B kinase complex is necessary and sufficient for NF-?B activation occurring in the cytosol" @default.
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• W2051879966 doi "https://doi.org/10.1002/eji.200425024" @default.
• W2051879966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15597322" @default.
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