FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051890167> ?p ?o ?g. }

• W2051890167 endingPage "9048" @default.
• W2051890167 startingPage "9044" @default.
• W2051890167 abstract "In addition to the important role of leukotrienes as mediators in allergy and inflammation, these compounds are also linked to pathophysiological events in the brain including cerebral ischemia, brain edema, and increased permeability of the blood-brain barrier in brain tumors. Although brain tumors have been shown to secrete leukotrienes, no studies to date have provided evidence for the tumor expression of genes encoding enzymes involved in leukotriene production. Therefore, the present study determined the abundance of the mRNA for arachidonate 5-lipoxygenase (5-LO; arachidonate:oxygen 5-oxidoreductase, EC 1.13.11.34), which is the rate-limiting enzyme in leukotriene synthesis, in a series of human brain tumors. Macrophage/monocyte infiltration of the tumor was estimated by measuring the abundance of the transcript for the 91-kDa glycoprotein phagocyte-specific oxidase (gp91-phox), which is the phagocyte-specific cytochrome b heavy chain. The present study shows that (i) the 5-LO transcript is expressed in normal bovine brain and in human brain tumors; (ii) the 5-LO gene in human brain tumors and in the dimethyl sulfoxide-induced promyelocytic human leukemic HL-60 cells is expressed as a multitranscript family (2.7, 3.1, 4.8, 6.4, 8.6 kilobases); and (iii) the abundance of 5-LO transcripts, the expression of the larger transcripts, and the 5-LO/gp91-phox ratio correlate with the tumor malignancy. Overall, the present study supports the hypothesis that the 5-LO gene product may play a role in human tumor-induced brain edemas and provides evidence for tumor-associated expression of high molecular weight 5-LO transcripts in human brain tumors." @default.
• W2051890167 created "2016-06-24" @default.
• W2051890167 creator A5019253871 @default.
• W2051890167 creator A5027480548 @default.
• W2051890167 creator A5040650353 @default.
• W2051890167 creator A5073892880 @default.
• W2051890167 date "1992-10-01" @default.
• W2051890167 modified "2023-10-01" @default.
• W2051890167 title "Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family." @default.
• W2051890167 cites W1488413741 @default.
• W2051890167 cites W1515427160 @default.
• W2051890167 cites W1560227765 @default.
• W2051890167 cites W1952049919 @default.
• W2051890167 cites W1964942556 @default.
• W2051890167 cites W1966620372 @default.
• W2051890167 cites W1987621344 @default.
• W2051890167 cites W1994132893 @default.
• W2051890167 cites W1994862373 @default.
• W2051890167 cites W2004351423 @default.
• W2051890167 cites W2014669590 @default.
• W2051890167 cites W2015292449 @default.
• W2051890167 cites W2024699328 @default.
• W2051890167 cites W2040096357 @default.
• W2051890167 cites W2046943612 @default.
• W2051890167 cites W2051183422 @default.
• W2051890167 cites W2051279958 @default.
• W2051890167 cites W2054044627 @default.
• W2051890167 cites W2056152917 @default.
• W2051890167 cites W2057422423 @default.
• W2051890167 cites W2066037602 @default.
• W2051890167 cites W2069886420 @default.
• W2051890167 cites W2083116460 @default.
• W2051890167 cites W2084997952 @default.
• W2051890167 cites W2089766043 @default.
• W2051890167 cites W2156792252 @default.
• W2051890167 cites W2171335844 @default.
• W2051890167 cites W2253771026 @default.
• W2051890167 cites W2412154753 @default.
• W2051890167 cites W3024734494 @default.
• W2051890167 doi "https://doi.org/10.1073/pnas.89.19.9044" @default.
• W2051890167 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/50061" @default.
• W2051890167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1357659" @default.
• W2051890167 hasPublicationYear "1992" @default.
• W2051890167 type Work @default.
• W2051890167 sameAs 2051890167 @default.
• W2051890167 citedByCount "68" @default.
• W2051890167 countsByYear W20518901672012 @default.
• W2051890167 countsByYear W20518901672013 @default.
• W2051890167 countsByYear W20518901672014 @default.
• W2051890167 countsByYear W20518901672015 @default.
• W2051890167 countsByYear W20518901672017 @default.
• W2051890167 countsByYear W20518901672019 @default.
• W2051890167 countsByYear W20518901672020 @default.
• W2051890167 countsByYear W20518901672021 @default.
• W2051890167 countsByYear W20518901672022 @default.
• W2051890167 countsByYear W20518901672023 @default.
• W2051890167 crossrefType "journal-article" @default.
• W2051890167 hasAuthorship W2051890167A5019253871 @default.
• W2051890167 hasAuthorship W2051890167A5027480548 @default.
• W2051890167 hasAuthorship W2051890167A5040650353 @default.
• W2051890167 hasAuthorship W2051890167A5073892880 @default.
• W2051890167 hasBestOaLocation W20518901671 @default.
• W2051890167 hasConcept C104317684 @default.
• W2051890167 hasConcept C150194340 @default.
• W2051890167 hasConcept C153911025 @default.
• W2051890167 hasConcept C169760540 @default.
• W2051890167 hasConcept C185592680 @default.
• W2051890167 hasConcept C203014093 @default.
• W2051890167 hasConcept C2776042228 @default.
• W2051890167 hasConcept C2776452501 @default.
• W2051890167 hasConcept C2777670902 @default.
• W2051890167 hasConcept C55493867 @default.
• W2051890167 hasConcept C86803240 @default.
• W2051890167 hasConceptScore W2051890167C104317684 @default.
• W2051890167 hasConceptScore W2051890167C150194340 @default.
• W2051890167 hasConceptScore W2051890167C153911025 @default.
• W2051890167 hasConceptScore W2051890167C169760540 @default.
• W2051890167 hasConceptScore W2051890167C185592680 @default.
• W2051890167 hasConceptScore W2051890167C203014093 @default.
• W2051890167 hasConceptScore W2051890167C2776042228 @default.
• W2051890167 hasConceptScore W2051890167C2776452501 @default.
• W2051890167 hasConceptScore W2051890167C2777670902 @default.
• W2051890167 hasConceptScore W2051890167C55493867 @default.
• W2051890167 hasConceptScore W2051890167C86803240 @default.
• W2051890167 hasIssue "19" @default.
• W2051890167 hasLocation W20518901671 @default.
• W2051890167 hasLocation W20518901672 @default.
• W2051890167 hasLocation W20518901673 @default.
• W2051890167 hasLocation W20518901674 @default.
• W2051890167 hasOpenAccess W2051890167 @default.
• W2051890167 hasPrimaryLocation W20518901671 @default.
• W2051890167 hasRelatedWork W1995478390 @default.
• W2051890167 hasRelatedWork W2009966535 @default.
• W2051890167 hasRelatedWork W2014590372 @default.
• W2051890167 hasRelatedWork W2036409480 @default.
• W2051890167 hasRelatedWork W2085668533 @default.
• W2051890167 hasRelatedWork W2127457813 @default.
• W2051890167 hasRelatedWork W2350911639 @default.

• next