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- W2051891423 abstract "Pretreatment of rats with 3-methylcholanthrene (3MC) or phenobarbital (PB) stimulates the incorporation of free amino acid into protein in a liver microsomal system (Gelboin and Sokoloff, 1961) dependent on endogenous or exogenous messenger RNA (Gelboin, 1964; Kato, et, al., 1965). The recent success in inhibiting the growth of tumors in animals and in tissue culture, with a whole range of terephthalanilide derivatives (Kensler, 1963; Burchenal, et, al., 1963) and with derivatives of indolyl-3-acetic acid (Norman and Schultz, 1965; Schultz and Norman, 1965) prompted this investigation into the effect of representative samples of these carcinostatic drugs on the stimulation of amino acid incorporation in a subcellular system which is normally brought about by pretreatment with PB or 3MC. The present paper shows that n-pentyl indolyl-3-acetate (pIAA) when co-administered with PB prevented the PB-induced stimulation of amino acid incorporation in, vitro. Simultaneous pretreatment with N, N''-bis (p-(N'-methylamidino) phenyl) terephthalamidine (NSC-57155) and with PB or 3MC only prevented the 3MC-induced stimulation of amino acid incorporation into protein in the rat liver sub-cellular system." @default.
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- W2051891423 date "1965-09-01" @default.
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- W2051891423 title "The effect of two carcinostatic agents on the chemically induced stimulation of amino acid incorporation in a mammalian system" @default.
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- W2051891423 doi "https://doi.org/10.1016/0006-291x(65)90087-2" @default.
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