FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051891646> ?p ?o ?g. }

• W2051891646 endingPage "14509" @default.
• W2051891646 startingPage "14504" @default.
• W2051891646 abstract "Mutations in the COX17 gene of Saccharomyces cerevisiae cause a respiratory deficiency due to a block in the production of a functional cytochrome oxidase complex. Because cox17 mutants are able to express both the mitochondrially and nuclearly encoded subunits of cytochrome oxidase, the Cox17p most likely affects some late posttranslational step of the assembly pathway. A fragment of yeast nuclear DNA capable of complementing the mutation has been cloned by transformation of the cox17 mutant with a library of genomic DNA. Subcloning and sequencing of the COX17 gene revealed that it codes for a cysteine-rich protein with a molecular weight of 8,057. Unlike other previously described accessory factors involved in cytochrome oxidase assembly, all of which are components of mitochondria, Cox17p is a cytoplasmic protein. The cytoplasmic location of Cox17p suggested that it might have a function in delivery of a prosthetic group to the holoenzyme. A requirement of Cox17p in providing the copper prosthetic group of cytochrome oxidase is supported by the finding that a cox17 null mutant is rescued by the addition of copper to the growth medium. Evidence is presented indicating that Cox17p is not involved in general copper metabolism in yeast but rather has a more specific function in the delivery of copper to mitochondria. Mutations in the COX17 gene of Saccharomyces cerevisiae cause a respiratory deficiency due to a block in the production of a functional cytochrome oxidase complex. Because cox17 mutants are able to express both the mitochondrially and nuclearly encoded subunits of cytochrome oxidase, the Cox17p most likely affects some late posttranslational step of the assembly pathway. A fragment of yeast nuclear DNA capable of complementing the mutation has been cloned by transformation of the cox17 mutant with a library of genomic DNA. Subcloning and sequencing of the COX17 gene revealed that it codes for a cysteine-rich protein with a molecular weight of 8,057. Unlike other previously described accessory factors involved in cytochrome oxidase assembly, all of which are components of mitochondria, Cox17p is a cytoplasmic protein. The cytoplasmic location of Cox17p suggested that it might have a function in delivery of a prosthetic group to the holoenzyme. A requirement of Cox17p in providing the copper prosthetic group of cytochrome oxidase is supported by the finding that a cox17 null mutant is rescued by the addition of copper to the growth medium. Evidence is presented indicating that Cox17p is not involved in general copper metabolism in yeast but rather has a more specific function in the delivery of copper to mitochondria." @default.
• W2051891646 created "2016-06-24" @default.
• W2051891646 creator A5000965741 @default.
• W2051891646 creator A5067593445 @default.
• W2051891646 creator A5067604299 @default.
• W2051891646 date "1996-06-01" @default.
• W2051891646 modified "2023-10-12" @default.
• W2051891646 title "Characterization of , a Yeast Gene Involved in Copper Metabolism and Assembly of Cytochrome Oxidase" @default.
• W2051891646 cites W1477052822 @default.
• W2051891646 cites W1485438242 @default.
• W2051891646 cites W1514437369 @default.
• W2051891646 cites W1573042704 @default.
• W2051891646 cites W1576198188 @default.
• W2051891646 cites W1637969949 @default.
• W2051891646 cites W170672763 @default.
• W2051891646 cites W1775749144 @default.
• W2051891646 cites W1921046052 @default.
• W2051891646 cites W1928774984 @default.
• W2051891646 cites W1967888351 @default.
• W2051891646 cites W1969060808 @default.
• W2051891646 cites W1974572661 @default.
• W2051891646 cites W1976713915 @default.
• W2051891646 cites W1985001103 @default.
• W2051891646 cites W1987630668 @default.
• W2051891646 cites W1992595091 @default.
• W2051891646 cites W2007354562 @default.
• W2051891646 cites W2007632640 @default.
• W2051891646 cites W2014669590 @default.
• W2051891646 cites W2028007077 @default.
• W2051891646 cites W2049849193 @default.
• W2051891646 cites W2055462482 @default.
• W2051891646 cites W2060730227 @default.
• W2051891646 cites W2089029010 @default.
• W2051891646 cites W2100837269 @default.
• W2051891646 cites W2101422765 @default.
• W2051891646 cites W2115073295 @default.
• W2051891646 cites W2147148910 @default.
• W2051891646 cites W2159686421 @default.
• W2051891646 cites W2321839534 @default.
• W2051891646 cites W238201244 @default.
• W2051891646 doi "https://doi.org/10.1074/jbc.271.24.14504" @default.
• W2051891646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8662933" @default.
• W2051891646 hasPublicationYear "1996" @default.
• W2051891646 type Work @default.
• W2051891646 sameAs 2051891646 @default.
• W2051891646 citedByCount "452" @default.
• W2051891646 countsByYear W20518916462012 @default.
• W2051891646 countsByYear W20518916462013 @default.
• W2051891646 countsByYear W20518916462014 @default.
• W2051891646 countsByYear W20518916462015 @default.
• W2051891646 countsByYear W20518916462016 @default.
• W2051891646 countsByYear W20518916462017 @default.
• W2051891646 countsByYear W20518916462018 @default.
• W2051891646 countsByYear W20518916462019 @default.
• W2051891646 countsByYear W20518916462020 @default.
• W2051891646 countsByYear W20518916462021 @default.
• W2051891646 countsByYear W20518916462022 @default.
• W2051891646 countsByYear W20518916462023 @default.
• W2051891646 crossrefType "journal-article" @default.
• W2051891646 hasAuthorship W2051891646A5000965741 @default.
• W2051891646 hasAuthorship W2051891646A5067593445 @default.
• W2051891646 hasAuthorship W2051891646A5067604299 @default.
• W2051891646 hasBestOaLocation W20518916461 @default.
• W2051891646 hasConcept C104317684 @default.
• W2051891646 hasConcept C123249941 @default.
• W2051891646 hasConcept C143065580 @default.
• W2051891646 hasConcept C153911025 @default.
• W2051891646 hasConcept C2777576037 @default.
• W2051891646 hasConcept C2779222958 @default.
• W2051891646 hasConcept C28859421 @default.
• W2051891646 hasConcept C501734568 @default.
• W2051891646 hasConcept C55493867 @default.
• W2051891646 hasConcept C86803240 @default.
• W2051891646 hasConceptScore W2051891646C104317684 @default.
• W2051891646 hasConceptScore W2051891646C123249941 @default.
• W2051891646 hasConceptScore W2051891646C143065580 @default.
• W2051891646 hasConceptScore W2051891646C153911025 @default.
• W2051891646 hasConceptScore W2051891646C2777576037 @default.
• W2051891646 hasConceptScore W2051891646C2779222958 @default.
• W2051891646 hasConceptScore W2051891646C28859421 @default.
• W2051891646 hasConceptScore W2051891646C501734568 @default.
• W2051891646 hasConceptScore W2051891646C55493867 @default.
• W2051891646 hasConceptScore W2051891646C86803240 @default.
• W2051891646 hasIssue "24" @default.
• W2051891646 hasLocation W20518916461 @default.
• W2051891646 hasOpenAccess W2051891646 @default.
• W2051891646 hasPrimaryLocation W20518916461 @default.
• W2051891646 hasRelatedWork W1516770101 @default.
• W2051891646 hasRelatedWork W1963983419 @default.
• W2051891646 hasRelatedWork W1982584572 @default.
• W2051891646 hasRelatedWork W2397070560 @default.
• W2051891646 hasRelatedWork W261727187 @default.
• W2051891646 hasRelatedWork W3200271510 @default.
• W2051891646 hasRelatedWork W4232406862 @default.
• W2051891646 hasRelatedWork W4240624121 @default.
• W2051891646 hasRelatedWork W4315558101 @default.
• W2051891646 hasRelatedWork W63366483 @default.
• W2051891646 hasVolume "271" @default.

• next