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• W2051935562 abstract "Cooperation between calcineurin (CN)-NFATc and RAF-MEK-ERK signaling pathways is essential in thymocyte positive selection. It is known that the Regulators of Calcineurin (RCAN) proteins can act either facilitating or suppressing CN-dependent signaling events. Here, we show that RCAN genes are expressed in lymphoid tissues, and address the role of RCAN proteins in T cell development. Overexpression of human RCAN3 and RCAN1 can modulate T cell development by increasing positive selection-related surface markers, as well as the Erk(hi) competence state in double positive thymocytes, a characteristic molecular signature of positive selection, without affecting CN activity. We also found that RCAN1/3 interact with RAF kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF kinases may influence T cell positive selection." @default.
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• W2051935562 date "2015-05-01" @default.
• W2051935562 modified "2023-10-06" @default.
• W2051935562 title "RCAN 1 and 3 proteins regulate thymic positive selection" @default.
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• W2051935562 doi "https://doi.org/10.1016/j.bbrc.2015.03.029" @default.
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