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• W2051940153 endingPage "1005" @default.
• W2051940153 startingPage "999" @default.
• W2051940153 abstract "The idea that tumors must escape from immune recognition contains the implicit assumption that tumors can be destroyed by immune responses either spontaneously or as the result of immunotherapeutic intervention. Simply put, there is no need for tumor escape without immunological pressure. Here, we review evidence supporting the immune escape hypothesis and critically explore the mechanisms that may allow such escape to occur. We discuss the idea that the central engine for generating immunoresistant tumor cell variants is the genomic instability and dysregulation that is characteristic of the transformed genome. Natural selection of heterogeneous tumor cells results in the survival and proliferation of variants that happen to possess genetic and epigenetic traits that facilitate their growth and immune evasion. Tumor escape variants are likely to emerge after treatment with increasingly effective immunotherapies." @default.
• W2051940153 created "2016-06-24" @default.
• W2051940153 creator A5014744153 @default.
• W2051940153 creator A5061987607 @default.
• W2051940153 date "2002-11-01" @default.
• W2051940153 modified "2023-10-01" @default.
• W2051940153 title "Natural selection of tumor variants in the generation of “tumor escape” phenotypes" @default.
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