Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051947374> ?p ?o ?g. }
- W2051947374 endingPage "18" @default.
- W2051947374 startingPage "11" @default.
- W2051947374 abstract "Congenital heart defects are the clinical manifestation of anomalies in embryonic cardiac development. Such defects occur in distinct regions or chambers of the heart. A molecular framework in which to consider cardiac development and congenital heart disease in a segmental fashion has begun to emerge. dHAND and eHAND are two related basic helix-loop-helix transcription factors that are expressed in a complementary fashion in the developing right and left ventricles, respectively. They are also expressed in the neural crest-derived cardiac outflow tract and aortic arch arteries. Targeted mutations of dHAND and eHAND in mice have revealed novel pathways of organogenesis in mesodermal and neural crest derivatives. dHAND mutants exhibit hypoplasia of the right ventricle, branchial arches, and aortic arch arteries. The distinct nature of cardiac defects in dHAND mutants provides an entry into dissecting molecular pathways governing morphogenesis of specific components of the heart. Congenital heart disease is considered as a defect in segmental development of the heart and the role of dHAND and eHAND in regulating such developmental pathways in normal and abnormal cardiogenesis is examined." @default.
- W2051947374 created "2016-06-24" @default.
- W2051947374 creator A5061410044 @default.
- W2051947374 date "1999-02-01" @default.
- W2051947374 modified "2023-10-10" @default.
- W2051947374 title "HAND Proteins Molecular Mediators of Cardiac Development and Congenital Heart Disease" @default.
- W2051947374 cites W109691843 @default.
- W2051947374 cites W1971977081 @default.
- W2051947374 cites W1974703394 @default.
- W2051947374 cites W1987460221 @default.
- W2051947374 cites W1993862102 @default.
- W2051947374 cites W1994193635 @default.
- W2051947374 cites W2001848617 @default.
- W2051947374 cites W2006909029 @default.
- W2051947374 cites W2015840464 @default.
- W2051947374 cites W2020128838 @default.
- W2051947374 cites W2021106046 @default.
- W2051947374 cites W2021338904 @default.
- W2051947374 cites W2023315904 @default.
- W2051947374 cites W2025281664 @default.
- W2051947374 cites W2034806302 @default.
- W2051947374 cites W2037241011 @default.
- W2051947374 cites W2040686597 @default.
- W2051947374 cites W2044792617 @default.
- W2051947374 cites W2050173039 @default.
- W2051947374 cites W2053797631 @default.
- W2051947374 cites W2060494385 @default.
- W2051947374 cites W2063679739 @default.
- W2051947374 cites W2064586774 @default.
- W2051947374 cites W2066747191 @default.
- W2051947374 cites W2068852923 @default.
- W2051947374 cites W2076718142 @default.
- W2051947374 cites W2077737520 @default.
- W2051947374 cites W2078587203 @default.
- W2051947374 cites W2101881948 @default.
- W2051947374 cites W2102609766 @default.
- W2051947374 cites W2112111700 @default.
- W2051947374 cites W2114563969 @default.
- W2051947374 cites W2120972584 @default.
- W2051947374 cites W2127387556 @default.
- W2051947374 cites W2135801344 @default.
- W2051947374 cites W2146046550 @default.
- W2051947374 cites W2148454249 @default.
- W2051947374 cites W2158085046 @default.
- W2051947374 cites W2168545181 @default.
- W2051947374 cites W2181488995 @default.
- W2051947374 cites W2184560410 @default.
- W2051947374 cites W2338642290 @default.
- W2051947374 cites W2736408517 @default.
- W2051947374 doi "https://doi.org/10.1016/s1050-1738(98)00033-4" @default.
- W2051947374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10189962" @default.
- W2051947374 hasPublicationYear "1999" @default.
- W2051947374 type Work @default.
- W2051947374 sameAs 2051947374 @default.
- W2051947374 citedByCount "90" @default.
- W2051947374 countsByYear W20519473742012 @default.
- W2051947374 countsByYear W20519473742014 @default.
- W2051947374 countsByYear W20519473742015 @default.
- W2051947374 countsByYear W20519473742016 @default.
- W2051947374 countsByYear W20519473742017 @default.
- W2051947374 countsByYear W20519473742018 @default.
- W2051947374 countsByYear W20519473742019 @default.
- W2051947374 countsByYear W20519473742020 @default.
- W2051947374 countsByYear W20519473742022 @default.
- W2051947374 crossrefType "journal-article" @default.
- W2051947374 hasAuthorship W2051947374A5061410044 @default.
- W2051947374 hasConcept C104317684 @default.
- W2051947374 hasConcept C105702510 @default.
- W2051947374 hasConcept C126322002 @default.
- W2051947374 hasConcept C126749454 @default.
- W2051947374 hasConcept C145103041 @default.
- W2051947374 hasConcept C196843134 @default.
- W2051947374 hasConcept C2775877586 @default.
- W2051947374 hasConcept C2776064143 @default.
- W2051947374 hasConcept C2776113144 @default.
- W2051947374 hasConcept C2777837822 @default.
- W2051947374 hasConcept C2778646171 @default.
- W2051947374 hasConcept C2778921608 @default.
- W2051947374 hasConcept C2779980429 @default.
- W2051947374 hasConcept C2780074459 @default.
- W2051947374 hasConcept C2780298129 @default.
- W2051947374 hasConcept C2780594696 @default.
- W2051947374 hasConcept C2781285907 @default.
- W2051947374 hasConcept C40692019 @default.
- W2051947374 hasConcept C54355233 @default.
- W2051947374 hasConcept C62425271 @default.
- W2051947374 hasConcept C71924100 @default.
- W2051947374 hasConcept C86803240 @default.
- W2051947374 hasConcept C95444343 @default.
- W2051947374 hasConceptScore W2051947374C104317684 @default.
- W2051947374 hasConceptScore W2051947374C105702510 @default.
- W2051947374 hasConceptScore W2051947374C126322002 @default.
- W2051947374 hasConceptScore W2051947374C126749454 @default.
- W2051947374 hasConceptScore W2051947374C145103041 @default.
- W2051947374 hasConceptScore W2051947374C196843134 @default.
- W2051947374 hasConceptScore W2051947374C2775877586 @default.
- W2051947374 hasConceptScore W2051947374C2776064143 @default.
- W2051947374 hasConceptScore W2051947374C2776113144 @default.