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• W2051949245 abstract "Abstract Background. Many pathways seem to be involved in the regulation of the intra-S-phase checkpoint after exposure to ionizing radiation, but the role of p53 has proven to be rather elusive. Here we have a closer look at the progression of irradiated cells through S-phase in dependence of their p53 status. Materials and methods. Three pairs of tumour cell lines were used, each consisting of one p53 functional and one p53 non-functional line. Cells were labelled with bromodeoxyuridine(BrdU) immediately after irradiation, they were then incubated in label-free medium, and at different times afterwards their position within the S-phase was determined by means of flow cytometry. Results. While in the p53 deficient cells progression through S-phase was slowed significantly over at least a few hours, it was halted for just about an hour in the p53 proficient cells and then proceeded without further delay or even at a slightly accelerated pace. Conclusions. It is clear from the experiments presented here that p53 does play a role for the progress of cells through the S-phase after X-ray exposure, but the exact mechanisms by which replicon initiation and elongation is controlled in irradiated cells remain to be elucidated." @default.
• W2051949245 created "2016-06-24" @default.
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• W2051949245 date "2014-11-05" @default.
• W2051949245 modified "2023-10-18" @default.
• W2051949245 title "Differential S-phase progression after irradiation of p53 functional versus non-functional tumour cells" @default.
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• W2051949245 doi "https://doi.org/10.2478/raon-2014-0032" @default.
• W2051949245 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4230555" @default.
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