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- W2051951569 abstract "Rats were used to examine the impact of systemic protein synthesis inhibition (PSI) on the reconsolidation of a contextually reactivated memory of conditioned taste aversion (CTA). Rats were administered intraperitoneal injections of saline or lithium chloride (LiCl; .15 M) following exposure to a novel sucrose solution in a unique context. Seven days later, rats were injected subcutaneously with saline or cycloheximide (CXM; 1 mg/kg) and returned to their home cage or placed into the CTA training context in the absence of the target conditioned stimulus to reactivate the training memory. At testing, LiCl-trained rats that had been given CXM at reactivation had significantly greater difference scores (sucrose-water) in comparison with LiCl/CXM rats that had not been given a reactivation treatment and LiCl/saline memory-reactivated rats. These results suggest that context re-exposure effectively reactivates memory of CTA training that may be weakened through PSI. Extinction tests revealed rapid attenuation of taste aversions in all of the LiCl-injected groups. The involvement of taste-potentiated aversions and the role of the context in taste aversion conditioning are discussed." @default.
- W2051951569 created "2016-06-24" @default.
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- W2051951569 date "2007-01-01" @default.
- W2051951569 modified "2023-09-23" @default.
- W2051951569 title "Cycloheximide impairs reconsolidation of a contextually reactivated memory in a conditioned taste aversion paradigm." @default.
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- W2051951569 doi "https://doi.org/10.1037/0735-7044.121.2.433" @default.
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