FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051954952> ?p ?o ?g. }

• W2051954952 endingPage "52" @default.
• W2051954952 startingPage "45" @default.
• W2051954952 abstract "Amino-hydroxypropylidene bisphosphonic acid (AHPrBP, previously APD) is a potent inhibitor of bone resorption. Since it remains in bone for a long time, and since it was not found to impair bone mineralization, it could be administered at high dose over a short period of time. Therefore, 11 patients with symptomatic Paget's disease received AHPrBP orally at 1200 mg/day over 5 consecutive days. Controls were performed after 1 month in all patients, 6 months in 8 patients, and one year in 4 patients. Clinical improvement and biochemical remission was observed in all patients, except one with severe disease. Side effects were negligible. Disease activity at bone scintigram decreased over 6 months. Plasma alkaline phosphatase activity fell progressively and significantly from 210 ± 26 U/I (x̄ ± SEM) to 103 ± 10 U/I after 6 months (nl < 120 U/I). Urinary excretion of hydroxyproline decreased immediately and became normal (nl < 2.3 μmol/IGF) as a mean at day 5 (from 4.6 ± 0.4 μmol/IGF to 2.1 ± 0.3 μmol/IGF). Thereafter it remained within the normal range (2.0 ± 0.2 μmol/l at day 180). Plasma calcium and phosphate concentrations fell transiently between day 4 and 15, whereas plasma PTH levels increased over this period of time. In conclusion, a short course of AHPrBP given per os at high dose induces a rapid decline in activity and remission of moderate Paget's disease, without significant side effects." @default.
• W2051954952 created "2016-06-24" @default.
• W2051954952 creator A5011404558 @default.
• W2051954952 creator A5041396751 @default.
• W2051954952 creator A5090577453 @default.
• W2051954952 date "2009-12-03" @default.
• W2051954952 modified "2023-09-25" @default.
• W2051954952 title "Paget's disease of bone treated in five days with AHPrBP (APD) per Os" @default.
• W2051954952 cites W1517837353 @default.
• W2051954952 cites W1963935558 @default.
• W2051954952 cites W1978920283 @default.
• W2051954952 cites W1995181451 @default.
• W2051954952 cites W2006953927 @default.
• W2051954952 cites W2013797802 @default.
• W2051954952 cites W2016859325 @default.
• W2051954952 cites W2024153163 @default.
• W2051954952 cites W2028022155 @default.
• W2051954952 cites W2030247921 @default.
• W2051954952 cites W2047034325 @default.
• W2051954952 cites W2047467283 @default.
• W2051954952 cites W2047495527 @default.
• W2051954952 cites W2049468378 @default.
• W2051954952 cites W2055505794 @default.
• W2051954952 cites W2060996955 @default.
• W2051954952 cites W2068880901 @default.
• W2051954952 cites W2069040041 @default.
• W2051954952 cites W2072579122 @default.
• W2051954952 cites W2074138272 @default.
• W2051954952 cites W2083116747 @default.
• W2051954952 cites W2089364695 @default.
• W2051954952 cites W2091940325 @default.
• W2051954952 cites W2095985832 @default.
• W2051954952 cites W2130289134 @default.
• W2051954952 cites W2161325107 @default.
• W2051954952 cites W2169978447 @default.
• W2051954952 cites W2224679701 @default.
• W2051954952 cites W2334809253 @default.
• W2051954952 cites W2337075852 @default.
• W2051954952 doi "https://doi.org/10.1002/jbmr.5650020108" @default.
• W2051954952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3455156" @default.
• W2051954952 hasPublicationYear "2009" @default.
• W2051954952 type Work @default.
• W2051954952 sameAs 2051954952 @default.
• W2051954952 citedByCount "31" @default.
• W2051954952 crossrefType "journal-article" @default.
• W2051954952 hasAuthorship W2051954952A5011404558 @default.
• W2051954952 hasAuthorship W2051954952A5041396751 @default.
• W2051954952 hasAuthorship W2051954952A5090577453 @default.
• W2051954952 hasConcept C10146269 @default.
• W2051954952 hasConcept C126322002 @default.
• W2051954952 hasConcept C134018914 @default.
• W2051954952 hasConcept C146562846 @default.
• W2051954952 hasConcept C160160445 @default.
• W2051954952 hasConcept C170033053 @default.
• W2051954952 hasConcept C181199279 @default.
• W2051954952 hasConcept C185592680 @default.
• W2051954952 hasConcept C2776154862 @default.
• W2051954952 hasConcept C2776169692 @default.
• W2051954952 hasConcept C2776541429 @default.
• W2051954952 hasConcept C2779134260 @default.
• W2051954952 hasConcept C2779797417 @default.
• W2051954952 hasConcept C55493867 @default.
• W2051954952 hasConcept C673006 @default.
• W2051954952 hasConcept C71924100 @default.
• W2051954952 hasConceptScore W2051954952C10146269 @default.
• W2051954952 hasConceptScore W2051954952C126322002 @default.
• W2051954952 hasConceptScore W2051954952C134018914 @default.
• W2051954952 hasConceptScore W2051954952C146562846 @default.
• W2051954952 hasConceptScore W2051954952C160160445 @default.
• W2051954952 hasConceptScore W2051954952C170033053 @default.
• W2051954952 hasConceptScore W2051954952C181199279 @default.
• W2051954952 hasConceptScore W2051954952C185592680 @default.
• W2051954952 hasConceptScore W2051954952C2776154862 @default.
• W2051954952 hasConceptScore W2051954952C2776169692 @default.
• W2051954952 hasConceptScore W2051954952C2776541429 @default.
• W2051954952 hasConceptScore W2051954952C2779134260 @default.
• W2051954952 hasConceptScore W2051954952C2779797417 @default.
• W2051954952 hasConceptScore W2051954952C55493867 @default.
• W2051954952 hasConceptScore W2051954952C673006 @default.
• W2051954952 hasConceptScore W2051954952C71924100 @default.
• W2051954952 hasIssue "1" @default.
• W2051954952 hasLocation W20519549521 @default.
• W2051954952 hasLocation W20519549522 @default.
• W2051954952 hasOpenAccess W2051954952 @default.
• W2051954952 hasPrimaryLocation W20519549521 @default.
• W2051954952 hasRelatedWork W1986049049 @default.
• W2051954952 hasRelatedWork W1987767691 @default.
• W2051954952 hasRelatedWork W2021907840 @default.
• W2051954952 hasRelatedWork W2032962339 @default.
• W2051954952 hasRelatedWork W2036148628 @default.
• W2051954952 hasRelatedWork W2091140190 @default.
• W2051954952 hasRelatedWork W2098104791 @default.
• W2051954952 hasRelatedWork W2115949432 @default.
• W2051954952 hasRelatedWork W2123650095 @default.
• W2051954952 hasRelatedWork W2327305388 @default.
• W2051954952 hasVolume "2" @default.
• W2051954952 isParatext "false" @default.
• W2051954952 isRetracted "false" @default.

• next