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- W2051961867 endingPage "3033" @default.
- W2051961867 startingPage "3017" @default.
- W2051961867 abstract "Ten years after its discovery, the small ubiquitin-like protein modifier (SUMO) has emerged as a key regulator of proteins. While early studies indicated that sumoylation takes place mainly in the nucleus, an increasing number of non-nuclear substrates have recently been identified, suggesting a wider stage for sumoylation in the cell. Unlike ubiquitylation, which primarily targets a substrate for degradation, sumoylation regulates a substrate's functions mainly by altering the intracellular localization, protein-protein interactions or other types of post-translational modifications. These changes in turn affect gene expression, genomic and chromosomal stability and integrity, and signal transduction. Sumoylation is counter-balanced by desumoylation, and well-balanced sumoylation is essential for normal cellular behaviors. Loss of the balance has been associated with a number of diseases. This paper reviews recent progress in the study of SUMO pathways, substrates, and cellular functions and highlights important findings that have accelerated advances in this study field and link sumoylation to human diseases." @default.
- W2051961867 created "2016-06-24" @default.
- W2051961867 creator A5042839840 @default.
- W2051961867 date "2007-09-04" @default.
- W2051961867 modified "2023-10-16" @default.
- W2051961867 title "Sumoylation regulates diverse biological processes" @default.
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