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• W2051962369 abstract "In the chick embryo fibroblast cell culture adenosine cyclic 3′:5′-monophosphate (cyclic AMP) stimulates ribonucleic acid biosynthesis (+50%), rRNA and tRNA as well as mRNA. The RNA pool size is enlarged and the specific activity elevated. Optimal concentration of cyclic AMP is 3—4 mM; it has to be present for 3 h in order to exert its full action. During this time the effect can be prevented by inhibitors of protein biosynthesis. The stimulation is not due to altered transport of the precursor [3H]uridine. Adenosine and adenosine 5′-monophosphate exhibit similar effects which, however, seem to result from another mechanism. It is felt that the action of cyclic AMP and similar compounds can only be explained through a pleiotropic effect (phosphorylation of histones, of RNA polymerase, induction of initiation and/or regulatory factors)." @default.
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• W2051962369 date "1973-08-01" @default.
• W2051962369 modified "2023-10-15" @default.
• W2051962369 title "Stimulation of Ribonucleic-Acid Synthesis in Chick-Embryo Fibroblasts by Exogenous Adenosine 3':5'-Monophosphate" @default.
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• W2051962369 doi "https://doi.org/10.1111/j.1432-1033.1973.tb02967.x" @default.
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