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- W205197678 abstract "Coagulation is the process by which a blood clot is formed in order to stop bleeding. It involves two main pathways – extrinsic and intrinsic pathways. The extrinsic pathway is initiated by tissue factor produced as a result of damaged blood vessels. The intrinsic pathway is initiated by contact activation. In this article, we discuss the clotting factors that make up both pathways and the central role of thrombin in coagulation. The formation of the fibrin blood clot is illustrated in a diagram. We also discuss negative regulators, which inhibit the clotting factors and briefly, the process by which the blood clot is broken down that is called fibrinolysis. Lastly, there is a discussion of the various tests used clinically to assess the function of the clotting factors." @default.
- W205197678 created "2016-06-24" @default.
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- W205197678 date "2014-01-01" @default.
- W205197678 modified "2023-09-25" @default.
- W205197678 title "Normal Coagulation and Hemostasis" @default.
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- W205197678 doi "https://doi.org/10.1016/b978-0-12-386456-7.07908-9" @default.
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