FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051976811> ?p ?o ?g. }

• W2051976811 endingPage "2480" @default.
• W2051976811 startingPage "2480" @default.
• W2051976811 abstract "The first hybrid molecule of a β-lactam antibiotic and a host defence peptide and a method for the preparation of this type of molecule are reported. Conjugation of an antimicrobial peptide to a cephalosporin, through a cleavable linker, reversibly masks one of the activity determinants of the peptide. Its release from the β-lactam core can be selectively triggered by bacterial enzymes (β-lactamases) which mediate resistance to β-lactam agents. A prototypical cephalothin-bactenecin candidate was synthesised, using a copper(I)-catalysed azide–alkyne cyclo-addition reaction for the conjugation step. Enzymatic hydrolysis assays of this candidate were initially performed with a purified β-lactamase to confirm that the peptide can be released from the cephalosporin. The antimicrobial activity of the conjugate was then assessed against representative strains of bacteria and compared to the activities of its parent β-lactam and peptide components and to those of two analogous conjugates based on non-cleavable linkers. The results of these assays indicate that the conjugate has an activity distinct from its separate constituents and that the release of the peptide from the cephalosporin may contribute to its mechanism of action. Furthermore, the results of antimicrobial assays performed with an isogenic strain of bacteria expressing or not an extended-spectrum β-lactamase, suggest that antimicrobial peptide prodrug candidates targeting resistant bacteria could be generated from these hybrid antibiotics." @default.
• W2051976811 created "2016-06-24" @default.
• W2051976811 creator A5007042472 @default.
• W2051976811 creator A5009000972 @default.
• W2051976811 creator A5011131195 @default.
• W2051976811 creator A5037404693 @default.
• W2051976811 creator A5047282815 @default.
• W2051976811 creator A5055973465 @default.
• W2051976811 creator A5072083241 @default.
• W2051976811 creator A5079757087 @default.
• W2051976811 creator A5089330086 @default.
• W2051976811 date "2012-01-01" @default.
• W2051976811 modified "2023-09-27" @default.
• W2051976811 title "β-Lactam-host defence peptide conjugates as antibiotic prodrug candidates targeting resistant bacteria" @default.
• W2051976811 cites W1504680783 @default.
• W2051976811 cites W1520392406 @default.
• W2051976811 cites W1538475853 @default.
• W2051976811 cites W1549521446 @default.
• W2051976811 cites W1964954592 @default.
• W2051976811 cites W1968652549 @default.
• W2051976811 cites W1977762520 @default.
• W2051976811 cites W1997152791 @default.
• W2051976811 cites W1999537900 @default.
• W2051976811 cites W2002114807 @default.
• W2051976811 cites W2013674343 @default.
• W2051976811 cites W2040169414 @default.
• W2051976811 cites W2040733257 @default.
• W2051976811 cites W2044059225 @default.
• W2051976811 cites W2046565365 @default.
• W2051976811 cites W2048858553 @default.
• W2051976811 cites W2053276301 @default.
• W2051976811 cites W2054602599 @default.
• W2051976811 cites W2059183805 @default.
• W2051976811 cites W2060306551 @default.
• W2051976811 cites W2061910359 @default.
• W2051976811 cites W2075663982 @default.
• W2051976811 cites W2078814682 @default.
• W2051976811 cites W2079665383 @default.
• W2051976811 cites W2101273146 @default.
• W2051976811 cites W2103567156 @default.
• W2051976811 cites W2106112964 @default.
• W2051976811 cites W2111667046 @default.
• W2051976811 cites W2125730798 @default.
• W2051976811 cites W2131192673 @default.
• W2051976811 cites W2142680296 @default.
• W2051976811 cites W2145662716 @default.
• W2051976811 cites W2162586071 @default.
• W2051976811 cites W2165224041 @default.
• W2051976811 cites W2168409658 @default.
• W2051976811 cites W2331738366 @default.
• W2051976811 cites W2952095992 @default.
• W2051976811 doi "https://doi.org/10.1039/c2ra01351g" @default.
• W2051976811 hasPublicationYear "2012" @default.
• W2051976811 type Work @default.
• W2051976811 sameAs 2051976811 @default.
• W2051976811 citedByCount "25" @default.
• W2051976811 countsByYear W20519768112012 @default.
• W2051976811 countsByYear W20519768112013 @default.
• W2051976811 countsByYear W20519768112014 @default.
• W2051976811 countsByYear W20519768112015 @default.
• W2051976811 countsByYear W20519768112016 @default.
• W2051976811 countsByYear W20519768112017 @default.
• W2051976811 countsByYear W20519768112018 @default.
• W2051976811 countsByYear W20519768112019 @default.
• W2051976811 countsByYear W20519768112020 @default.
• W2051976811 countsByYear W20519768112021 @default.
• W2051976811 countsByYear W20519768112022 @default.
• W2051976811 countsByYear W20519768112023 @default.
• W2051976811 crossrefType "journal-article" @default.
• W2051976811 hasAuthorship W2051976811A5007042472 @default.
• W2051976811 hasAuthorship W2051976811A5009000972 @default.
• W2051976811 hasAuthorship W2051976811A5011131195 @default.
• W2051976811 hasAuthorship W2051976811A5037404693 @default.
• W2051976811 hasAuthorship W2051976811A5047282815 @default.
• W2051976811 hasAuthorship W2051976811A5055973465 @default.
• W2051976811 hasAuthorship W2051976811A5072083241 @default.
• W2051976811 hasAuthorship W2051976811A5079757087 @default.
• W2051976811 hasAuthorship W2051976811A5089330086 @default.
• W2051976811 hasConcept C108215921 @default.
• W2051976811 hasConcept C134306372 @default.
• W2051976811 hasConcept C185592680 @default.
• W2051976811 hasConcept C197336794 @default.
• W2051976811 hasConcept C21951064 @default.
• W2051976811 hasConcept C2779281246 @default.
• W2051976811 hasConcept C33923547 @default.
• W2051976811 hasConcept C4937899 @default.
• W2051976811 hasConcept C501593827 @default.
• W2051976811 hasConcept C523546767 @default.
• W2051976811 hasConcept C54355233 @default.
• W2051976811 hasConcept C55493867 @default.
• W2051976811 hasConcept C64778159 @default.
• W2051976811 hasConcept C86803240 @default.
• W2051976811 hasConcept C89423630 @default.
• W2051976811 hasConceptScore W2051976811C108215921 @default.
• W2051976811 hasConceptScore W2051976811C134306372 @default.
• W2051976811 hasConceptScore W2051976811C185592680 @default.
• W2051976811 hasConceptScore W2051976811C197336794 @default.
• W2051976811 hasConceptScore W2051976811C21951064 @default.

• next