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- W2051979969 abstract "Abstract Changes in eicosanoid production may contribute to some of the complications of the aging process such as atherosclerosis and glomerular sclerosis. Polyunsaturated fatty acids of the n‐6 and n‐3 series are precursors of eicosanoids. We fed diets containing safflower oil as a source of n‐6 fatty acids, fish oil as a source of n‐3 fatty acids or beef tallow as a source of saturated fats to three groups of normal rats from 2–18 months of age. We demonstrated incorporation of the n‐3 fatty acids, 20:5n‐3 and 22:6n‐3 into kidney phospholipids. Feeding of the diet containing n‐3 fatty acids was associated with a markedly decreased giomerular production of PGE, 6‐keto‐PGF 1α and TXB 2 . It also decreased the aortic production of 6‐keto‐PGF 1α and platelet production of TXB 2 . No significant effect of n‐6 fatty acids on dienoic eicosanoid production was observed. There were no adverse effects on kidney function as measured by urinary protein excretion and serum creatinine levels or on renal morphology by any diet. A diet enriched in n‐3 fatty acids for 18 months remains effective in decreasing dienoic eicosanoids in the aging rat." @default.
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- W2051979969 date "1988-04-01" @default.
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- W2051979969 title "The influence of n-6 and n-3 fatty acids on kidney phospholipid composition and on eicosanoid production in aging rats" @default.
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- W2051979969 doi "https://doi.org/10.1007/bf02537339" @default.
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