FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051987103> ?p ?o ?g. }

• W2051987103 endingPage "2486" @default.
• W2051987103 startingPage "2479" @default.
• W2051987103 abstract "LEARNING OBJECTIVES On completion of this article, the reader should be able to: Define absolute and relative adrenal insufficiency. Explain the responses for low- and high-dose adrenocorticotropic hormone (ACTH)-stimulation tests. Use this information in a clinical setting. All of the authors have disclosed that they have no financial relationships with or interests in any commercial companies pertaining to this educational activity. Wolters Kluwer Health has identified and resolved all faculty conflicts of interest regarding this educational activity. Visit the Critical Care Medicine Web site (www.ccmjournal.org) for information on obtaining continuing medical education credit. Objective: To compare a low-dose (1 μg) corticotropin stimulation test with the more standard (250 μg) test for the diagnosis of relative adrenal insufficiency. Design: Diagnostic study. Setting: Thirty-one-bed mixed medico-surgical department of intensive care. Patients: Forty-six consecutive patients with septic shock. Interventions: Corticotropin stimulation tests (low-dose test, 1 μg, and standard 250-μg test), performed consecutively at an interval >4 hrs. Measurements and Main Results: In each test, serum cortisol levels were measured before (T0) and 30 (T30), 60 (T60), and 90 (T90) mins after corticotropin injection. The maximal increase in cortisol (Δmax) was calculated as the difference between T0 and the highest cortisol value at T30, T60, or T90 and considered as adequate if >9 μg/dL (250 nmol/L). Nonresponders to the low-dose test had a lower survival rate than responders to both tests (27 vs. 47%, p = .06; Kaplan Meier curves). Interestingly, nonresponders to high-dose test received hydrocortisone treatment and had a similar survival to responders. Multivariable logistic regression disclosed that the response to the combined low-dose test and high-dose test was an independent predictor of survival (odds ratio 28.91, 95% confidence interval 1.81–462.70, p = .017), whereas basal or maximal cortisol levels in both tests were not. Conclusions: The low-dose test identified a subgroup of patients in septic shock with inadequate adrenal reserve who had a worse outcome and would have been missed by the high-dose test. These patients may also benefit from glucocorticoid replacement therapy." @default.
• W2051987103 created "2016-06-24" @default.
• W2051987103 creator A5003379719 @default.
• W2051987103 creator A5022420045 @default.
• W2051987103 creator A5035964974 @default.
• W2051987103 creator A5043482559 @default.
• W2051987103 creator A5052177345 @default.
• W2051987103 creator A5086315304 @default.
• W2051987103 creator A5089156253 @default.
• W2051987103 date "2005-11-01" @default.
• W2051987103 modified "2023-10-18" @default.
• W2051987103 title "Relative adrenal insufficiency in patients with septic shock: Comparison of low-dose and conventional corticotropin tests*" @default.
• W2051987103 cites W1898928487 @default.
• W2051987103 cites W1966077517 @default.
• W2051987103 cites W1971885333 @default.
• W2051987103 cites W1975932764 @default.
• W2051987103 cites W1981465100 @default.
• W2051987103 cites W1985854089 @default.
• W2051987103 cites W1986495016 @default.
• W2051987103 cites W1992311120 @default.
• W2051987103 cites W2011606289 @default.
• W2051987103 cites W2027977470 @default.
• W2051987103 cites W2028709971 @default.
• W2051987103 cites W2038182822 @default.
• W2051987103 cites W2042268246 @default.
• W2051987103 cites W2047770015 @default.
• W2051987103 cites W2049105058 @default.
• W2051987103 cites W2052375478 @default.
• W2051987103 cites W2053980980 @default.
• W2051987103 cites W2060004264 @default.
• W2051987103 cites W2073060575 @default.
• W2051987103 cites W2073276747 @default.
• W2051987103 cites W2073862919 @default.
• W2051987103 cites W2083380272 @default.
• W2051987103 cites W2087301662 @default.
• W2051987103 cites W2110862369 @default.
• W2051987103 cites W2120316262 @default.
• W2051987103 cites W2120658378 @default.
• W2051987103 cites W2125017989 @default.
• W2051987103 cites W2126105025 @default.
• W2051987103 cites W2135414391 @default.
• W2051987103 cites W2143734001 @default.
• W2051987103 cites W2155711152 @default.
• W2051987103 cites W2156618518 @default.
• W2051987103 cites W2166962064 @default.
• W2051987103 cites W2550507245 @default.
• W2051987103 cites W2599527603 @default.
• W2051987103 cites W4293242440 @default.
• W2051987103 doi "https://doi.org/10.1097/01.ccm.0000185641.87051.7c" @default.
• W2051987103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16276169" @default.
• W2051987103 hasPublicationYear "2005" @default.
• W2051987103 type Work @default.
• W2051987103 sameAs 2051987103 @default.
• W2051987103 citedByCount "112" @default.
• W2051987103 countsByYear W20519871032012 @default.
• W2051987103 countsByYear W20519871032013 @default.
• W2051987103 countsByYear W20519871032014 @default.
• W2051987103 countsByYear W20519871032015 @default.
• W2051987103 countsByYear W20519871032016 @default.
• W2051987103 countsByYear W20519871032017 @default.
• W2051987103 countsByYear W20519871032018 @default.
• W2051987103 countsByYear W20519871032019 @default.
• W2051987103 countsByYear W20519871032020 @default.
• W2051987103 countsByYear W20519871032023 @default.
• W2051987103 crossrefType "journal-article" @default.
• W2051987103 hasAuthorship W2051987103A5003379719 @default.
• W2051987103 hasAuthorship W2051987103A5022420045 @default.
• W2051987103 hasAuthorship W2051987103A5035964974 @default.
• W2051987103 hasAuthorship W2051987103A5043482559 @default.
• W2051987103 hasAuthorship W2051987103A5052177345 @default.
• W2051987103 hasAuthorship W2051987103A5086315304 @default.
• W2051987103 hasAuthorship W2051987103A5089156253 @default.
• W2051987103 hasConcept C126322002 @default.
• W2051987103 hasConcept C151730666 @default.
• W2051987103 hasConcept C177713679 @default.
• W2051987103 hasConcept C24998067 @default.
• W2051987103 hasConcept C2777267654 @default.
• W2051987103 hasConcept C2777628635 @default.
• W2051987103 hasConcept C2778065167 @default.
• W2051987103 hasConcept C2778129406 @default.
• W2051987103 hasConcept C2778384902 @default.
• W2051987103 hasConcept C2778709874 @default.
• W2051987103 hasConcept C2780546910 @default.
• W2051987103 hasConcept C2781300812 @default.
• W2051987103 hasConcept C2987404301 @default.
• W2051987103 hasConcept C71315377 @default.
• W2051987103 hasConcept C71924100 @default.
• W2051987103 hasConcept C86803240 @default.
• W2051987103 hasConceptScore W2051987103C126322002 @default.
• W2051987103 hasConceptScore W2051987103C151730666 @default.
• W2051987103 hasConceptScore W2051987103C177713679 @default.
• W2051987103 hasConceptScore W2051987103C24998067 @default.
• W2051987103 hasConceptScore W2051987103C2777267654 @default.
• W2051987103 hasConceptScore W2051987103C2777628635 @default.
• W2051987103 hasConceptScore W2051987103C2778065167 @default.
• W2051987103 hasConceptScore W2051987103C2778129406 @default.
• W2051987103 hasConceptScore W2051987103C2778384902 @default.
• W2051987103 hasConceptScore W2051987103C2778709874 @default.

• next