FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051993844> ?p ?o ?g. }

• W2051993844 endingPage "420" @default.
• W2051993844 startingPage "412" @default.
• W2051993844 abstract "The increasing number of recent outbreaks of HPAI H5N1 in birds and humans brings out an urgent need to develop potent H5N1 vaccine regimens. Here we present a study on the intranasal vaccination of recombinant baculovirus surface-displayed hemagglutinin (BacHA) or inactivated whole H5N1 viral (IWV) vaccine with a recombinant cholera toxin B subunit (rCTB) as a mucosal adjuvant in a BALB/c mouse model. Two groups of mice were vaccinated with different doses (HA titer of log 24 or log 28) of either HA surface-displayed baculovirus or inactivated whole viral vaccine virus adjuvanted with different doses (2 μg or 10 μg) of rCTB. The vaccinations were repeated after 28 days. HA specific serum IgG and mucosal IgA antibodies were quantified by indirect ELISA, and serum neutralizing antibody titer were estimated by hemagglutination inhibition (HI) assay and virus neutralization titer assay. Functional protective efficacy of the vaccine was assessed by host challenge against HPAI H5N1 strains. The results revealed that mice co-administered with log 28 HA titer of BacHA vaccine and adjuvanted with 10 μg of rCTB had a significantly enhanced serum IgG and mucosal IgA immune response and serum microneutralization titer compared with mice administered with unadjuvanted log 24 or log 28 HA titer of BacHA alone. Also vaccination with 10 μg of rCTB and log 28 HA titer of BacHA elicited higher HA specific serum and mucosal antibody levels and serum HI titer than vaccination with log 28 HA titer of inactivated H5N1 virus adjuvanted with the same dose of rCTB. The host challenge study also showed that 10 μg rCTB combined with log 28 HA titer of BacHA provided 100% protection against 10MLD50 of homologous and heterologous H5N1 strains. The study shows that the combination of rH5 HA expressed on baculovirus surface and rCTB mucosal adjuvant form an effective mucosal vaccine against H5N1 infection. This baculovirus surface-displayed vaccine is more efficacious than inactivated H5N1 influenza vaccine when administered by intranasal route and has no biosafety concerns associated with isolation, purification and production of the latter vaccine." @default.
• W2051993844 created "2016-06-24" @default.
• W2051993844 creator A5020906213 @default.
• W2051993844 creator A5057285400 @default.
• W2051993844 creator A5059218908 @default.
• W2051993844 creator A5062504863 @default.
• W2051993844 creator A5066224718 @default.
• W2051993844 creator A5066461716 @default.
• W2051993844 creator A5084855643 @default.
• W2051993844 date "2008-10-01" @default.
• W2051993844 modified "2023-09-26" @default.
• W2051993844 title "Protective immunity against influenza H5N1 virus challenge in mice by intranasal co-administration of baculovirus surface-displayed HA and recombinant CTB as an adjuvant" @default.
• W2051993844 cites W1541711548 @default.
• W2051993844 cites W1966893415 @default.
• W2051993844 cites W2003615530 @default.
• W2051993844 cites W2016198028 @default.
• W2051993844 cites W2017690097 @default.
• W2051993844 cites W2019759746 @default.
• W2051993844 cites W2025333144 @default.
• W2051993844 cites W2026437767 @default.
• W2051993844 cites W2032842265 @default.
• W2051993844 cites W2036596307 @default.
• W2051993844 cites W2062447823 @default.
• W2051993844 cites W2075704126 @default.
• W2051993844 cites W2084385678 @default.
• W2051993844 cites W2085914831 @default.
• W2051993844 cites W2121448471 @default.
• W2051993844 cites W2130897866 @default.
• W2051993844 cites W2132493567 @default.
• W2051993844 cites W2133364035 @default.
• W2051993844 cites W2141844606 @default.
• W2051993844 cites W2147699573 @default.
• W2051993844 cites W2152912310 @default.
• W2051993844 cites W2158855166 @default.
• W2051993844 cites W2327078538 @default.
• W2051993844 cites W2088932875 @default.
• W2051993844 doi "https://doi.org/10.1016/j.virol.2008.08.002" @default.
• W2051993844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18786689" @default.
• W2051993844 hasPublicationYear "2008" @default.
• W2051993844 type Work @default.
• W2051993844 sameAs 2051993844 @default.
• W2051993844 citedByCount "63" @default.
• W2051993844 countsByYear W20519938442012 @default.
• W2051993844 countsByYear W20519938442013 @default.
• W2051993844 countsByYear W20519938442014 @default.
• W2051993844 countsByYear W20519938442015 @default.
• W2051993844 countsByYear W20519938442016 @default.
• W2051993844 countsByYear W20519938442017 @default.
• W2051993844 countsByYear W20519938442018 @default.
• W2051993844 countsByYear W20519938442019 @default.
• W2051993844 countsByYear W20519938442020 @default.
• W2051993844 countsByYear W20519938442021 @default.
• W2051993844 crossrefType "journal-article" @default.
• W2051993844 hasAuthorship W2051993844A5020906213 @default.
• W2051993844 hasAuthorship W2051993844A5057285400 @default.
• W2051993844 hasAuthorship W2051993844A5059218908 @default.
• W2051993844 hasAuthorship W2051993844A5062504863 @default.
• W2051993844 hasAuthorship W2051993844A5066224718 @default.
• W2051993844 hasAuthorship W2051993844A5066461716 @default.
• W2051993844 hasAuthorship W2051993844A5084855643 @default.
• W2051993844 hasBestOaLocation W20519938441 @default.
• W2051993844 hasConcept C159047783 @default.
• W2051993844 hasConcept C159654299 @default.
• W2051993844 hasConcept C203014093 @default.
• W2051993844 hasConcept C22070199 @default.
• W2051993844 hasConcept C22889606 @default.
• W2051993844 hasConcept C2522874641 @default.
• W2051993844 hasConcept C2777546802 @default.
• W2051993844 hasConcept C2777863537 @default.
• W2051993844 hasConcept C2779261636 @default.
• W2051993844 hasConcept C32611913 @default.
• W2051993844 hasConcept C519248777 @default.
• W2051993844 hasConcept C85663871 @default.
• W2051993844 hasConcept C86803240 @default.
• W2051993844 hasConcept C8891405 @default.
• W2051993844 hasConcept C89423630 @default.
• W2051993844 hasConceptScore W2051993844C159047783 @default.
• W2051993844 hasConceptScore W2051993844C159654299 @default.
• W2051993844 hasConceptScore W2051993844C203014093 @default.
• W2051993844 hasConceptScore W2051993844C22070199 @default.
• W2051993844 hasConceptScore W2051993844C22889606 @default.
• W2051993844 hasConceptScore W2051993844C2522874641 @default.
• W2051993844 hasConceptScore W2051993844C2777546802 @default.
• W2051993844 hasConceptScore W2051993844C2777863537 @default.
• W2051993844 hasConceptScore W2051993844C2779261636 @default.
• W2051993844 hasConceptScore W2051993844C32611913 @default.
• W2051993844 hasConceptScore W2051993844C519248777 @default.
• W2051993844 hasConceptScore W2051993844C85663871 @default.
• W2051993844 hasConceptScore W2051993844C86803240 @default.
• W2051993844 hasConceptScore W2051993844C8891405 @default.
• W2051993844 hasConceptScore W2051993844C89423630 @default.
• W2051993844 hasIssue "2" @default.
• W2051993844 hasLocation W20519938441 @default.
• W2051993844 hasLocation W20519938442 @default.
• W2051993844 hasOpenAccess W2051993844 @default.
• W2051993844 hasPrimaryLocation W20519938441 @default.
• W2051993844 hasRelatedWork W1984647379 @default.
• W2051993844 hasRelatedWork W2051993844 @default.

• next