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- W2051994865 abstract "Objective: Numerous physicians are loath to prescribe hormone replacement therapy (HRT) for women with elevated blood pressure (BP) because of their concern that hypertension might worsen. Studies have advocated that Drospirenone combined with estradiol significantly reduces BP in postmenopausal women with hypertension. Design and Method: In the present study, we examined the effects of estradiol / norethindrone acetate on 24-h ambulatory blood pressure (ABPM) in 182 hypertensive postmenopausal women (PMW, 52 ± 2 [mean ± SE] years, BMI 21.81 ± 3.29 kg/m2). Validated, Meditech ABPM 05 ambulatory blood pressure monitor was used to obtain 24-h BP before and during six months therapy with estradiol / norethindrone acetate. Most women did not change antihypertensive treatment during the study. Results and Conclusions: After six months on HRT BP was lowered by an average of 1 mmHg systolic and 2 mmHg diastolic per day and per night BP was lowered by an average of 2 mmHg systolic and 1 mmHg diastolic. BP reductions were not significantly lower with regard to systolic or diastolic BP before initiation of HRT nor to action on day and night-time BP. BP reduction in PMW with hypertension after six months receiving estradiol / norethindrone acetate may lower the physicians concern that hypertension might worsen if they prescribe HRT. Hormone replacement therapy should be considered as a first line therapy in postmenopausal women with hypertension if there is no contraindication." @default.
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- W2051994865 date "2010-06-01" @default.
- W2051994865 modified "2023-10-06" @default.
- W2051994865 title "ESTRADIOL/NORETHINDRONE THERAPY EFFECT ON AMBULATORY BLOOD PRESSURE IN HYPERTENSIVE POSTMENOPAUSAL WOMEN: PP.18.189" @default.
- W2051994865 doi "https://doi.org/10.1097/01.hjh.0000379115.99166.fd" @default.
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