FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051997364> ?p ?o ?g. }

• W2051997364 endingPage "1208" @default.
• W2051997364 startingPage "1199" @default.
• W2051997364 abstract "Insulin gene transcription is critical for the maintenance of pancreatic beta-cell differentiation and insulin production. In this study, we found that the basic helix-loop-helix transcription factor Mad, which usually acts as a repressor to c-Myc, enhances insulin gene transcription. In isolated rat islets adenoviral overexpression of Mad augmented insulin mRNA expression and insulin protein content, as well as glucokinase and GLUT2 mRNA expression. Also, Mad overexpression upregulated insulin promoter activity in beta-cell-derived cell lines, MIN6 and betaTC1, as well as in non-insulin producing liver cell line, HepG2. Mad overexpression in rat islets enhanced PDX-1 expression and its DNA binding activity. We found that Mad mediated increased PDX-1 expression by an E-box dependent transcriptional regulation of the PDX-1 gene. That the effects of Mad on insulin expression were mediated through PDX-1 was further substantiated by studies showing inhibition of insulin promoter activation by Mad in the presence of mutated PDX-1 binding site. Although Mad functions as a negative regulatory factor for multiple target genes, these studies establish the fact that Mad can also function as a positive regulatory factor for insulin gene transcription. Such regulation of insulin expression by Mad with modulation of PDX-1 expression and DNA binding activity could offer useful therapeutic and/or experimental tools to promote insulin production in appropriate cell types." @default.
• W2051997364 created "2016-06-24" @default.
• W2051997364 creator A5024295858 @default.
• W2051997364 creator A5049223531 @default.
• W2051997364 creator A5053160478 @default.
• W2051997364 creator A5070508954 @default.
• W2051997364 creator A5087833336 @default.
• W2051997364 creator A5089733820 @default.
• W2051997364 date "2003-04-01" @default.
• W2051997364 modified "2023-10-17" @default.
• W2051997364 title "Induction of Mad expression leads to augmentation of insulin gene transcription" @default.
• W2051997364 cites W153919731 @default.
• W2051997364 cites W1573536022 @default.
• W2051997364 cites W1627567497 @default.
• W2051997364 cites W1830287761 @default.
• W2051997364 cites W1918701699 @default.
• W2051997364 cites W1967766455 @default.
• W2051997364 cites W1970290322 @default.
• W2051997364 cites W1975740413 @default.
• W2051997364 cites W1992836970 @default.
• W2051997364 cites W2002423027 @default.
• W2051997364 cites W2005688198 @default.
• W2051997364 cites W2021550936 @default.
• W2051997364 cites W2027161267 @default.
• W2051997364 cites W2029167057 @default.
• W2051997364 cites W2029452578 @default.
• W2051997364 cites W2031204411 @default.
• W2051997364 cites W2032770280 @default.
• W2051997364 cites W2035843625 @default.
• W2051997364 cites W2038818919 @default.
• W2051997364 cites W2047632234 @default.
• W2051997364 cites W2048056915 @default.
• W2051997364 cites W2050876365 @default.
• W2051997364 cites W2056200154 @default.
• W2051997364 cites W2058218780 @default.
• W2051997364 cites W2063909610 @default.
• W2051997364 cites W2071978660 @default.
• W2051997364 cites W2075829878 @default.
• W2051997364 cites W2076641459 @default.
• W2051997364 cites W2077742875 @default.
• W2051997364 cites W2080546358 @default.
• W2051997364 cites W2082044596 @default.
• W2051997364 cites W2096706659 @default.
• W2051997364 cites W2097483279 @default.
• W2051997364 cites W2097774235 @default.
• W2051997364 cites W2106210346 @default.
• W2051997364 cites W2108394804 @default.
• W2051997364 cites W2114220325 @default.
• W2051997364 cites W2116209576 @default.
• W2051997364 cites W2118862408 @default.
• W2051997364 cites W2121266425 @default.
• W2051997364 cites W2123615908 @default.
• W2051997364 cites W2123766698 @default.
• W2051997364 cites W2135435990 @default.
• W2051997364 cites W2138701894 @default.
• W2051997364 cites W2146127531 @default.
• W2051997364 cites W2146383332 @default.
• W2051997364 cites W2157518285 @default.
• W2051997364 cites W2166421062 @default.
• W2051997364 cites W2320732213 @default.
• W2051997364 cites W4230665539 @default.
• W2051997364 cites W4241834352 @default.
• W2051997364 cites W4253422011 @default.
• W2051997364 cites W4322703507 @default.
• W2051997364 doi "https://doi.org/10.1016/s0006-291x(03)00493-5" @default.
• W2051997364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12684063" @default.
• W2051997364 hasPublicationYear "2003" @default.
• W2051997364 type Work @default.
• W2051997364 sameAs 2051997364 @default.
• W2051997364 citedByCount "5" @default.
• W2051997364 crossrefType "journal-article" @default.
• W2051997364 hasAuthorship W2051997364A5024295858 @default.
• W2051997364 hasAuthorship W2051997364A5049223531 @default.
• W2051997364 hasAuthorship W2051997364A5053160478 @default.
• W2051997364 hasAuthorship W2051997364A5070508954 @default.
• W2051997364 hasAuthorship W2051997364A5087833336 @default.
• W2051997364 hasAuthorship W2051997364A5089733820 @default.
• W2051997364 hasConcept C101762097 @default.
• W2051997364 hasConcept C104317684 @default.
• W2051997364 hasConcept C112446052 @default.
• W2051997364 hasConcept C121587040 @default.
• W2051997364 hasConcept C134018914 @default.
• W2051997364 hasConcept C138885662 @default.
• W2051997364 hasConcept C150194340 @default.
• W2051997364 hasConcept C153911025 @default.
• W2051997364 hasConcept C158448853 @default.
• W2051997364 hasConcept C165220095 @default.
• W2051997364 hasConcept C179926584 @default.
• W2051997364 hasConcept C191370860 @default.
• W2051997364 hasConcept C197902417 @default.
• W2051997364 hasConcept C2776828364 @default.
• W2051997364 hasConcept C2777391703 @default.
• W2051997364 hasConcept C2779306644 @default.
• W2051997364 hasConcept C41895202 @default.
• W2051997364 hasConcept C54355233 @default.
• W2051997364 hasConcept C82183700 @default.
• W2051997364 hasConcept C86339819 @default.
• W2051997364 hasConcept C86803240 @default.

• next