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• W2051998511 abstract "Abstract Infection of cells derived from three different mammalian species with any one of six strains of EHV-1 resulted in a 5- to 10-fold increase in the deoxythymidine kinase (dTK) activity when assayed in the presence of 100 μM dTTP. Increased dTK activity was also demonstrated in liver homogenates prepared from EHV-1-infected Syrian hamsters. Antibody elicited against the EHV-1 dTK induced in horse cells neutralized the enzyme activity induced by EHV-1 infection of horse, mouse, hamster, and monkey cells but not the dTKs of uninfected, nonequine cells. EHV-1 induction of dTK was confirmed by demonstration of the inability of the virus strains to replicate in the presence of arabinosylthymine (ara-T) in cells which themselves were totally resistant to the drug. Mutants of EHV-1 resistant to 5-bromodeoxyuridine and ara-T and lacking the ability to induce dTK activity (dTK − ) were also isolated. Electrophoretic analysis of cell extracts in polyacrylamide gels revealed a new peak of dTK activity ( R f = 0.25) after EHV-1 infection of some cell types (e.g., dTK − 3T3 cells, owl monkey kidney cells, etc.). Other cell types, whose cytosol dTK migrated with an R f (0.25) identical with that of the EHV-1 enzyme, contained no new electrophoretic peak of dTK activity after infection. In these latter infected cells, however, the dTK activity with an R f value of 0.25 was partially inhibited by anti-(EHV-1) serum, partially resistant to 100 μM dTTP, and displayed activity even with CTP as a phosphate donor, suggesting that, in these particular cell types, the EHV-1-induced dTK and the host cell cytosol dTK co-electrophorese. These results indicate that infection of cells with all strains of EHV-1 results in the induction of a new, virus-coded dTK activity." @default.
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• W2051998511 date "1978-10-01" @default.
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• W2051998511 title "Induction of deoxythymidine kinase activity in several mammalian cell lines after infection with six different strains of equine herpesvirus type 1 (EHV-1)" @default.
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• W2051998511 doi "https://doi.org/10.1016/0042-6822(78)90319-7" @default.
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