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- W2052007670 abstract "Methicillin resistant Staphylococcus aureus (MRSA) is a major health problem that has created a pressing need for new antibiotics. Compounds that inhibit the S. aureus SrtA sortase may function as potent anti-infective agents as this enzyme attaches virulence factors to the cell wall. Using high-throughput screening, we have identified several compounds that inhibit the enzymatic activity of the SrtA. A structure-activity relationship (SAR) analysis led to the identification of several pyridazinone and pyrazolethione analogs that inhibit SrtA with IC(50) values in the sub-micromolar range. Many of these molecules also inhibit the sortase enzyme from Bacillus anthracis suggesting that they may be generalized sortase inhibitors." @default.
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- W2052007670 date "2009-10-01" @default.
- W2052007670 modified "2023-10-14" @default.
- W2052007670 title "Discovery and structure–activity relationship analysis of Staphylococcus aureus sortase A inhibitors" @default.
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- W2052007670 doi "https://doi.org/10.1016/j.bmc.2009.08.067" @default.
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