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- W2052012061 endingPage "259" @default.
- W2052012061 startingPage "251" @default.
- W2052012061 abstract "Immaturity of the immune system has been suggested as an underlying factor for the high rate of morbidity and mortality from infections in newborns. Functional impairment of neonatal T cells is frequently quoted as the main underlying mechanism for such immaturity. However, recent studies suggest that neonatal antigen-presenting cells (APCs) also exhibit functional alterations, which could lead to secondary defects of adaptive T-cell responses. In this review, we summarize what is known on the functionality of APC at birth and during early childhood. Compared to adults, neonatal APCs display markers of immaturity and produce low levels of cytokines. Multiple factors could be involved in neonatal APC alteration, such as intrinsic immaturity, defective interaction between APCs and T cells and regulatory T-cell-mediated inhibition. Characterization of the relative contribution of each mechanism is clearly needed to better understand the functional capability of the neonatal immune system." @default.
- W2052012061 created "2016-06-24" @default.
- W2052012061 creator A5000522424 @default.
- W2052012061 creator A5037373612 @default.
- W2052012061 creator A5057365611 @default.
- W2052012061 date "2006-12-01" @default.
- W2052012061 modified "2023-09-25" @default.
- W2052012061 title "Defective antigen-presenting cell function in human neonates" @default.
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