Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052012904> ?p ?o ?g. }
- W2052012904 endingPage "65" @default.
- W2052012904 startingPage "57" @default.
- W2052012904 abstract "Although sleep complaints are very common among pregnant women, the potential adverse effects of sleep disturbance on the offspring are not well studied. Growing evidence suggests that maternal stress can induce an inflammatory environment on the fetal development. But people are not sure about the consequences of prenatal stress such as the inflammatory responses induced by maternal sleep deprivation (MSD). In the present study, we investigated the effects of MSD on long-term behavioral and cognitive consequences in offspring and its underlying inflammatory response pathway. The pregnant Wistar rats received prolonged sleep deprivation (72h) on gestational day (GD) 4, 9, and 18, respectively. The post-natal day (PND) 21 offspring showed impaired hippocampus-dependent spatial learning and memory in the Morris Water Maze task and anhedonia in sucrose preference experiment. Quantification of BrdU(+) and DCX(+) cells revealed a significant decrease in hippocampus neurogenesis in prepuberty offspring, especially for the late MSD (GD 18) group. Real-time RT-PCR showed that after MSD, the expression of pro-inflammatory cytokines (IL-1β, IL-6 and TNFα) increased in the hippocampus of offspring on PND 1, 7, 14 and 21, whereas anti-inflammatory cytokine IL-10 reduced at the same time. Immunofluorescence found that the cells of activated microglia were higher in the brains of MSD offspring. Taken together, these results suggested that the MSD-induced inflammatory response is an important factor for neurogenesis impairment and neurobehavioral outcomes in prepuberty offspring." @default.
- W2052012904 created "2016-06-24" @default.
- W2052012904 creator A5003746751 @default.
- W2052012904 creator A5006628583 @default.
- W2052012904 creator A5007046565 @default.
- W2052012904 creator A5019274000 @default.
- W2052012904 creator A5067694881 @default.
- W2052012904 creator A5071758171 @default.
- W2052012904 date "2014-08-01" @default.
- W2052012904 modified "2023-10-17" @default.
- W2052012904 title "Maternal sleep deprivation inhibits hippocampal neurogenesis associated with inflammatory response in young offspring rats" @default.
- W2052012904 cites W152231878 @default.
- W2052012904 cites W1764972970 @default.
- W2052012904 cites W1968745677 @default.
- W2052012904 cites W1970606114 @default.
- W2052012904 cites W1975498998 @default.
- W2052012904 cites W1977581346 @default.
- W2052012904 cites W1987566523 @default.
- W2052012904 cites W1990953930 @default.
- W2052012904 cites W1996059296 @default.
- W2052012904 cites W1996588072 @default.
- W2052012904 cites W1996885616 @default.
- W2052012904 cites W1998944910 @default.
- W2052012904 cites W2004349171 @default.
- W2052012904 cites W2010037905 @default.
- W2052012904 cites W2010180745 @default.
- W2052012904 cites W2013184659 @default.
- W2052012904 cites W2015380243 @default.
- W2052012904 cites W2015548551 @default.
- W2052012904 cites W2016612502 @default.
- W2052012904 cites W2017097604 @default.
- W2052012904 cites W2018819086 @default.
- W2052012904 cites W2027048265 @default.
- W2052012904 cites W2033840911 @default.
- W2052012904 cites W2034427457 @default.
- W2052012904 cites W2035487697 @default.
- W2052012904 cites W2044821086 @default.
- W2052012904 cites W2049840063 @default.
- W2052012904 cites W2051639780 @default.
- W2052012904 cites W2052687507 @default.
- W2052012904 cites W2054865354 @default.
- W2052012904 cites W2061809825 @default.
- W2052012904 cites W2066370652 @default.
- W2052012904 cites W2067267561 @default.
- W2052012904 cites W2067499927 @default.
- W2052012904 cites W2067844273 @default.
- W2052012904 cites W2072878021 @default.
- W2052012904 cites W2074895600 @default.
- W2052012904 cites W2075808524 @default.
- W2052012904 cites W2076190056 @default.
- W2052012904 cites W2076644456 @default.
- W2052012904 cites W2078577857 @default.
- W2052012904 cites W2089224748 @default.
- W2052012904 cites W2091221706 @default.
- W2052012904 cites W2096946076 @default.
- W2052012904 cites W2099416285 @default.
- W2052012904 cites W2101895351 @default.
- W2052012904 cites W2101898118 @default.
- W2052012904 cites W2107609959 @default.
- W2052012904 cites W2109759840 @default.
- W2052012904 cites W2110729320 @default.
- W2052012904 cites W2111271085 @default.
- W2052012904 cites W2112262501 @default.
- W2052012904 cites W2114481621 @default.
- W2052012904 cites W2121256019 @default.
- W2052012904 cites W2125266115 @default.
- W2052012904 cites W2131016140 @default.
- W2052012904 cites W2137554480 @default.
- W2052012904 cites W2139075903 @default.
- W2052012904 cites W2140167265 @default.
- W2052012904 cites W2144186309 @default.
- W2052012904 cites W2146316688 @default.
- W2052012904 cites W2147377777 @default.
- W2052012904 cites W2151400960 @default.
- W2052012904 cites W2154880023 @default.
- W2052012904 cites W2160779535 @default.
- W2052012904 cites W2163759450 @default.
- W2052012904 cites W2164173275 @default.
- W2052012904 cites W2165189852 @default.
- W2052012904 cites W40781248 @default.
- W2052012904 cites W52020851 @default.
- W2052012904 doi "https://doi.org/10.1016/j.nbd.2014.04.008" @default.
- W2052012904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24769004" @default.
- W2052012904 hasPublicationYear "2014" @default.
- W2052012904 type Work @default.
- W2052012904 sameAs 2052012904 @default.
- W2052012904 citedByCount "69" @default.
- W2052012904 countsByYear W20520129042015 @default.
- W2052012904 countsByYear W20520129042016 @default.
- W2052012904 countsByYear W20520129042017 @default.
- W2052012904 countsByYear W20520129042018 @default.
- W2052012904 countsByYear W20520129042019 @default.
- W2052012904 countsByYear W20520129042020 @default.
- W2052012904 countsByYear W20520129042021 @default.
- W2052012904 countsByYear W20520129042022 @default.
- W2052012904 countsByYear W20520129042023 @default.
- W2052012904 crossrefType "journal-article" @default.
- W2052012904 hasAuthorship W2052012904A5003746751 @default.