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• W2052020189 abstract "No AccessJournal of UrologyInvestigative Urology1 Sep 2012Cause of Residual Urine in Bladder Outlet Obstruction: An Experimental Study in the Rat Jianwen Zeng, Chuzao Pan, Chonghe Jiang, and Sivert Lindström Jianwen ZengJianwen Zeng Department of Urology, Qingyuan City People's Hospital of Jinan University, Guangdong, People's Republic of China More articles by this author , Chuzao PanChuzao Pan Department of Urology, Qingyuan City People's Hospital of Jinan University, Guangdong, People's Republic of China More articles by this author , Chonghe JiangChonghe Jiang Department of Urology, Qingyuan City People's Hospital of Jinan University, Guangdong, People's Republic of China Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden More articles by this author , and Sivert LindströmSivert Lindström Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.04.101AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We explored the role of bladder mechanoreceptors in post-void residual urine in rats with bladder outlet obstruction. Materials and Methods: Partial bladder outlet obstruction was induced by a urethral ligature in 11 adult female Sprague-Dawley® rats. Nine sham operated rats served as controls. The outcome was evaluated in acute experiments using α-chloralose anesthesia 6 weeks later. Bladders were catheterized for infusion, pressure recording and intravesical electrical stimulation. Bladder efferent activity was recorded from a thin pelvic nerve branch close to the bladder. Micturition contractions were triggered at different bladder volumes by a brief train of electrical stimulation of bladder afferents while monitoring post-stimulus efferent activity and reflex bladder contractions. The degree of obstruction was assessed by bladder wet weight at the end of the experiment. Results: Bladder weight, micturition threshold volume, anatomical bladder capacity and peak contraction force were significantly increased in obstructed rats. In sham operated controls a triggered micturition reflex was sustained by afferent feedback from the bladder until the bladder was empty. In contrast, reflex discharges failed with substantial volume remaining in the bladder in obstructed rats. The minimal micturition reflex volume correlated positively with bladder weight, micturition threshold volume and maximal bladder capacity (r ≥0.74). Conclusions: In rats with partial bladder outlet obstruction the micturition reflex failed before the bladder was empty due to a decreased afferent drive from bladder mechanoreceptors. Similar changes may contribute to post-void residual urine in humans with bladder outlet obstruction. References 1 : The nervous mechanism of micturition. Q J Exp Physiol1914; 8: 33. Google Scholar 2 : Nervous control of the urinary bladder of the cat. Brain Res1975; 87: 201. Google Scholar 3 : The neural control of micturition. Nat Rev Neurosci2008; 9: 453. Google Scholar 4 : Tension receptors in the stomach and the urinary bladder. J Physiol (Lond)1955; 128: 593. Google Scholar 5 : Rhythmic activity in pelvic efferents to the bladder: an experimental study in the cat with reference to the clinical condition ‘unstable bladder’. Urol Int1984; 39: 272. Google Scholar 6 : Electrical stimulation: A physiologic approach to the treatment of urinary incontinence. Urol Clin North Am1991; 18: 393. Google Scholar 7 : The dynamics of obstructed micturition. Invest Urol1964; 2: 188. Google Scholar 8 : Bladder mechanoreceptor changes after artificial bladder outlet obstruction in the anesthetized rat. Neurourol Urodyn2012; 31: 178. Google Scholar 9 : Changes in contractile properties in hypertrophic rat urinary bladder. J Urol1982; 128: 1340. Link, Google Scholar 10 : Intravesical electrical stimulation induces a prolonged decrease in micturition threshold volume in the rat. J Urol1996; 155: 1477. Link, Google Scholar 11 : Recurrent inhibition in sacral parasympathetic pathways to the bladder. J Physiol (Lond)1968; 196: 579. Google Scholar 12 : Recurrent inhibition of the bladder C fibre reflex in the cat and its response to naloxone. J Physiol (Lond)2006; 575: 603. Google Scholar 13 : Effects of partial outflow obstruction on bladder contractility and blood flow to the detrusor: comparison between mild and severe obstruction. Urol Int1997; 59: 226. Google Scholar 14 : alpha-Chloralose alters autonomic reflex function of the lower urinary tract. Am J Physiol1991; 261: R1560. Google Scholar 15 : Cystometrical evaluation of bladder instability in rats with infravesical outflow obstruction. J Urol1987; 137: 1291. Link, Google Scholar 16 : On the nature of bladder sensation: the concept of sensory modulation. Neurourol Urodyn2011; 30: 1220. Google Scholar 17 : Toward a new classification of overactive bladders. Neurourol Urodyn1995; 14: 635. Google Scholar © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byAndersson K (2018) This Month in Investigative UrologyJournal of Urology, VOL. 188, NO. 3, (692-693), Online publication date: 1-Sep-2012. Volume 188Issue 3September 2012Page: 1027-1032 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.Keywordsratsmechanoreceptorsurinary bladderreflexurinary bladder neck obstructionSprague-DawleyMetricsAuthor Information Jianwen Zeng Department of Urology, Qingyuan City People's Hospital of Jinan University, Guangdong, People's Republic of China More articles by this author Chuzao Pan Department of Urology, Qingyuan City People's Hospital of Jinan University, Guangdong, People's Republic of China More articles by this author Chonghe Jiang Department of Urology, Qingyuan City People's Hospital of Jinan University, Guangdong, People's Republic of China Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden More articles by this author Sivert Lindström Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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