FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052022392> ?p ?o ?g. }

• W2052022392 endingPage "818" @default.
• W2052022392 startingPage "814" @default.
• W2052022392 abstract "The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase produces superoxide, thus regulating redox state in the vessel wall. Three single-nucleotide polymorphisms (SNPs; −930A/G, A640G and C242T) of the p22phox subunit have been associated with hypertension; however, their role in peripheral and central pressures in normotensive individuals has not been addressed. A total of 210 healthy, normotensive individuals were studied. Genotypes for the −930A/G, A640G and C242T polymorphisms were determined by polymerase chain reaction. Peripheral pressures were measured by mercury sphygmomanometer and aortic pressures by a validated device using applanation tonometry. Both peripheral and central pressures differed across −930A/G genotypes. G allele carriers showed higher levels of peripheral systolic blood pressure (PSBP; AA: 113±12, GG/AG: 119±12 mm Hg; P<0.01) and peripheral diastolic blood pressure (AA: 70±9, GG/AG: 73±10 mm Hg; P<0.05). Regarding central pressures, AA homozygotes had lower central systolic blood pressure (CSBP; AA: 103±12, GG/AG: 108±12 mm Hg; P<0.01) and central diastolic blood pressure (AA: 71±9, GG/AG: 74±10 mm Hg; P<0.05). In multiple linear regression analysis, presence of the G allele (AG or GG) independently predicted CSBP. Blood pressure levels did not differ across A640G and C242T genotypes. The −930A/G polymorphism of p22phox is a determinant of peripheral and central pressures in normotensive individuals. The G allele is associated with higher blood pressure in the brachial artery, as well as in the aorta. These findings further elucidate the role of this polymorphism in the regulation of blood pressure. In contrast, the A640G and C242T SNPs do not influence peripheral and central pressures in normotensives." @default.
• W2052022392 created "2016-06-24" @default.
• W2052022392 creator A5002250840 @default.
• W2052022392 creator A5005228083 @default.
• W2052022392 creator A5005228981 @default.
• W2052022392 creator A5032584545 @default.
• W2052022392 creator A5066469848 @default.
• W2052022392 creator A5090681155 @default.
• W2052022392 creator A5091691708 @default.
• W2052022392 date "2010-05-27" @default.
• W2052022392 modified "2023-10-11" @default.
• W2052022392 title "The effect of p22phox −930A/G, A640G and C242T polymorphisms of NADPH oxidase on peripheral and central pressures in healthy, normotensive individuals" @default.
• W2052022392 cites W1969469718 @default.
• W2052022392 cites W1969912304 @default.
• W2052022392 cites W1984299707 @default.
• W2052022392 cites W1989994240 @default.
• W2052022392 cites W1995635950 @default.
• W2052022392 cites W1998603001 @default.
• W2052022392 cites W2000625731 @default.
• W2052022392 cites W2016913364 @default.
• W2052022392 cites W2058586184 @default.
• W2052022392 cites W2060897834 @default.
• W2052022392 cites W2070588731 @default.
• W2052022392 cites W2070926750 @default.
• W2052022392 cites W2078593792 @default.
• W2052022392 cites W2087318819 @default.
• W2052022392 cites W2094420414 @default.
• W2052022392 cites W2098990645 @default.
• W2052022392 cites W2105948848 @default.
• W2052022392 cites W2107509703 @default.
• W2052022392 cites W2112748083 @default.
• W2052022392 cites W2124561899 @default.
• W2052022392 cites W2132039169 @default.
• W2052022392 cites W2132287412 @default.
• W2052022392 cites W2134892659 @default.
• W2052022392 cites W2138209376 @default.
• W2052022392 cites W2145898095 @default.
• W2052022392 cites W2150481012 @default.
• W2052022392 cites W2155394219 @default.
• W2052022392 cites W2155578604 @default.
• W2052022392 cites W2165730407 @default.
• W2052022392 cites W2171523242 @default.
• W2052022392 cites W2171815293 @default.
• W2052022392 cites W2316746149 @default.
• W2052022392 doi "https://doi.org/10.1038/hr.2010.78" @default.
• W2052022392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20505675" @default.
• W2052022392 hasPublicationYear "2010" @default.
• W2052022392 type Work @default.
• W2052022392 sameAs 2052022392 @default.
• W2052022392 citedByCount "16" @default.
• W2052022392 countsByYear W20520223922012 @default.
• W2052022392 countsByYear W20520223922013 @default.
• W2052022392 countsByYear W20520223922014 @default.
• W2052022392 countsByYear W20520223922015 @default.
• W2052022392 countsByYear W20520223922018 @default.
• W2052022392 crossrefType "journal-article" @default.
• W2052022392 hasAuthorship W2052022392A5002250840 @default.
• W2052022392 hasAuthorship W2052022392A5005228083 @default.
• W2052022392 hasAuthorship W2052022392A5005228981 @default.
• W2052022392 hasAuthorship W2052022392A5032584545 @default.
• W2052022392 hasAuthorship W2052022392A5066469848 @default.
• W2052022392 hasAuthorship W2052022392A5090681155 @default.
• W2052022392 hasAuthorship W2052022392A5091691708 @default.
• W2052022392 hasBestOaLocation W20520223921 @default.
• W2052022392 hasConcept C104317684 @default.
• W2052022392 hasConcept C126322002 @default.
• W2052022392 hasConcept C134018914 @default.
• W2052022392 hasConcept C135763542 @default.
• W2052022392 hasConcept C153209595 @default.
• W2052022392 hasConcept C180754005 @default.
• W2052022392 hasConcept C181199279 @default.
• W2052022392 hasConcept C185592680 @default.
• W2052022392 hasConcept C2776151105 @default.
• W2052022392 hasConcept C2777989768 @default.
• W2052022392 hasConcept C2779719074 @default.
• W2052022392 hasConcept C2781308076 @default.
• W2052022392 hasConcept C38485361 @default.
• W2052022392 hasConcept C46762472 @default.
• W2052022392 hasConcept C55493867 @default.
• W2052022392 hasConcept C71924100 @default.
• W2052022392 hasConcept C84393581 @default.
• W2052022392 hasConceptScore W2052022392C104317684 @default.
• W2052022392 hasConceptScore W2052022392C126322002 @default.
• W2052022392 hasConceptScore W2052022392C134018914 @default.
• W2052022392 hasConceptScore W2052022392C135763542 @default.
• W2052022392 hasConceptScore W2052022392C153209595 @default.
• W2052022392 hasConceptScore W2052022392C180754005 @default.
• W2052022392 hasConceptScore W2052022392C181199279 @default.
• W2052022392 hasConceptScore W2052022392C185592680 @default.
• W2052022392 hasConceptScore W2052022392C2776151105 @default.
• W2052022392 hasConceptScore W2052022392C2777989768 @default.
• W2052022392 hasConceptScore W2052022392C2779719074 @default.
• W2052022392 hasConceptScore W2052022392C2781308076 @default.
• W2052022392 hasConceptScore W2052022392C38485361 @default.
• W2052022392 hasConceptScore W2052022392C46762472 @default.
• W2052022392 hasConceptScore W2052022392C55493867 @default.
• W2052022392 hasConceptScore W2052022392C71924100 @default.
• W2052022392 hasConceptScore W2052022392C84393581 @default.

• next