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- W2052030900 abstract "Upper GI bleeding is a common clinical condition associated with considerable morbidity and mortality. 1 Barkun A. Leontiadis G. Systematic review of the symptom burden, quality of life impairment and costs associated with peptic ulcer disease. Am J Med. 2010; 123: 358-366.e2 Abstract Full Text Full Text PDF PubMed Scopus (73) Google Scholar Conventional treatment modalities, such as injection and thermal and mechanical therapies 2 Gralnek I.M. Barkun A.N. Bardou M. Management of acute bleeding from a peptic ulcer. New Engl J Med. 2008; 359: 928-937 Crossref PubMed Scopus (287) Google Scholar used alone or in combination, typically achieve hemostasis in more than 90% of cases. 3 Fallah M.A. Prakash C. Edmundowicz S. Acute gastrointestinal bleeding. Med Clin N Am. 2000; 84: 1183-1208 Abstract Full Text Full Text PDF PubMed Scopus (95) Google Scholar However, treatment of recurrent bleeding (necessary in 10%-30%) introduces additional limitations and adverse events. 4 Marmo R. Rotondano G. Bianco M.A. et al. Outcome of endoscopic treatment for peptic ulcer bleeding: Is a second look necessary? A meta-analysis. Gastrointest Endosc. 2003; 57: 62-67 Abstract Full Text Full Text PDF PubMed Scopus (106) Google Scholar Epinephrine injection is associated with high rates of recurrent bleeding, and thermal therapies can cause tissue injury. 5 Park W.G. Yeh R.W. Triadafilopoulos G. Injection therapies for nonvariceal bleeding disorders of the GI tract. Gastrointest Endosc. 2007; 66: 343-354 Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar , 6 Chung S.C. Lau J.Y. Rutgeerts P. et al. Thermal coagulation for nonvariceal bleeding. Endoscopy. 2002; 34: 89-92 Crossref PubMed Scopus (11) Google Scholar Mechanical methods can be technically challenging and require specialized endoscopic expertise. These conventional modalities also can be challenging during treatment of diffuse, widespread bleeding." @default.
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- W2052030900 date "2013-07-01" @default.
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- W2052030900 title "Early experience with a novel hemostatic powder used to treat upper GI bleeding related to malignancies or after therapeutic interventions (with videos)" @default.
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